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SML0094

Sigma-Aldrich

Bikinin

≥98% (HPLC)

Sinônimo(s):

4-((5-Bromo-2-pyridinyl)amino)-4-oxobutanoic acid, 4-[(5-Bromo-2-pyridinyl)amino]-4-oxo-butanoic acid, Abrasin

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About This Item

Fórmula empírica (Notação de Hill):
C9H9BrN2O3
Número CAS:
188011-69-0
Peso molecular:
273.08
Número MDL:
MFCD00116442
Código UNSPSC:
12352200
ID de substância PubChem:
329825152
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

powder

cor

white to tan

solubilidade

DMSO: ≥5 mg/mL

aplicação(ões)

agriculture

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

OC(=O)CCC(=O)Nc1ccc(Br)cn1

InChI

1S/C9H9BrN2O3/c10-6-1-2-7(11-5-6)12-8(13)3-4-9(14)15/h1-2,5H,3-4H2,(H,14,15)(H,11,12,13)

chave InChI

XFYYQDHEDOXWGA-UHFFFAOYSA-N

Aplicação

Bikinin has been used:
  • as a glycogen synthase kinase-3 (GSK3) inhibitor in Arabidopsis Col-0 seedlings to test its effect on gene expression
  • as a component of induction medium and as a GSK3 inhibitor to test its effect on mesophyll cells in Arabidopsis leaf discs or cotyledons
  • as a brassinosteroid agonist to test its effect on the leaf index of R. trichophyllus terrestrial leaves

Ações bioquímicas/fisiológicas

Bikinin is a strong activator of brassinosteroid (BR) signaling. It is an Arabidopsis GSK-3 Inhibitor, an Arabidopsis SHAGGY-related Kinase Inhibitor, and a GSK-3-like Kinase BIN2 Inhibitor. Bikinin directly inhibits BIN2 (group II GSK3s) by interfering with ATP binding. Bikinin is specific toward a subset of Arabidopsis GSK3 kinases including BIN2 and ASK α, γ, ε, ι, and θ.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Bert De Rybel et al.
Chemistry & biology, 16(6), 594-604 (2009-06-25)
Glycogen synthase kinase 3 (GSK3) is a key regulator in signaling pathways in both animals and plants. Three Arabidopsis thaliana GSK3s are shown to be related to brassinosteroid (BR) signaling. In a phenotype-based compound screen we identified bikinin, a small
Ami N Saito et al.
Plant direct, 3(9), e00172-e00172 (2019-09-25)
Casein kinase 1 (CK1) is an evolutionarily conserved protein kinase family among eukaryotes. Studies in non-plants have shown CK1-dependent divergent biological processes, but the collective knowledge regarding the biological roles of plant CK1 lags far behind other members of the
Moritz Graeff et al.
Current biology : CB, 30(9), 1626-1638 (2020-03-30)
The plant vasculature is an essential adaptation to terrestrial growth. Its phloem component permits efficient transfer of photosynthates between source and sink organs but also transports signals that systemically coordinate physiology and development. Here, we provide evidence that developing phloem
Stella Bernardo-García et al.
Genes & development, 28(15), 1681-1694 (2014-08-03)
Signaling by the hormones brassinosteroid (BR) and gibberellin (GA) is critical to normal plant growth and development and is required for hypocotyl elongation in response to dark and elevated temperatures. Active BR signaling is essential for GA promotion of hypocotyl

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