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SML0949

Sigma-Aldrich

4μ8C

≥98% (HPLC)

Sinônimo(s):

7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde

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About This Item

Fórmula empírica (Notação de Hill):
C11H8O4
Número CAS:
14003-96-4
Peso molecular:
204.18
Código UNSPSC:
12352200
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

powder

cor

white to beige

solubilidade

DMSO: 5 mg/mL, clear (warmed)

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

O1c2c(ccc(c2C=O)O)C(=CC1=O)C

InChI

1S/C11H8O4/c1-6-4-10(14)15-11-7(6)2-3-9(13)8(11)5-12/h2-5,13H,1H3

chave InChI

RTHHSXOVIJWFQP-UHFFFAOYSA-N

Categorias relacionadas

Ações bioquímicas/fisiológicas

4μ8C is a potent inhibitor of the ER transmembrane protein IRE1, which mediates the unfolded protein response. 4μ8C inhibits regulated IRE1-dependent degradation (RIDD) and unconventional spicing of XBP1 mRNA in response to endopasmic reticulum (ER) stress, but has no affect on the kinase activity of IRE1.
4μ8C is a potent inhibitor of the ER transmembrane protein IRE1.
4μ8C is a salicylaldehyde derivative and its inhibitory action targets the K907 lysine residue in RNase (ribonuclease) domain and affects IRE1α (endoplasmic reticulum to nucleus signaling 1) RNase activity. In vitro analysis proved that 4μ8C was able to inhibit the release of insulin at high glucose levels.

Características e benefícios

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
027M4735V
024M4718V

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4μ8C inhibits insulin secretion independent of IRE1α RNase activity.
Sato H, et al.
Cell Structure and Function, 42(1), 61-70 (2017)
Su Xian et al.
EMBO reports, 22(12), e52509-e52509 (2021-10-27)
Aneuploidy is a chromosomal abnormality associated with poor prognosis in many cancer types. Here, we tested the hypothesis that the unfolded protein response (UPR) mechanistically links aneuploidy and local immune dysregulation. Using a single somatic copy number alteration (SCNA) score
Jirka Peschek et al.
EMBO reports, 16(12), 1688-1698 (2015-10-21)
The kinase/endonuclease IRE1 is the most conserved signal transducer of the unfolded protein response (UPR), an intracellular signaling network that monitors and regulates the protein folding capacity of the endoplasmic reticulum (ER). Upon sensing protein folding perturbations in the ER
Targeting the IRE1α?XBP1 branch of the unfolded protein response in human diseases.
Jiang D, et al.
Seminars in Cancer Biology, 33, 48-56 (2015)
Zhiyuan Fang et al.
Journal of dairy science, 105(8), 6895-6908 (2022-07-16)
Endoplasmic reticulum (ER) stress can be induced by various stimuli and triggers the unfolded protein response to activate intracellular signaling pathways that are mediated by 3 ER-resident sensors: inositol requiring protein-1α (IRE1α), PKR-like ER kinase (PERK), and activating transcription factor-6
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