SML0021

PDI inhibitor 16F16

≥98% (HPLC)

• Sinônimo(s): 2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylic acid methyl ester, Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate
• Fórmula empírica (Notação de Hill): C₁₆H₁₇ClN₂O₃
• Número CAS: 922507-80-0
• Peso molecular: 320.77
• Número MDL: MFCD20134198
• Código UNSPSC: 12352200
• ID de substância PubChem: 329825093
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to tan
• solubilidade: DMSO: 12 mg/mL, clear
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: COC(=O)C1(C)N(CCc2c1[nH]c3ccccc23)C(=O)CCl
• InChI: 1S/C16H17ClN2O3/c1-16(15(21)22-2)14-11(7-8-19(16)13(20)9-17)10-5-3-4-6-12(10)18-14/h3-6,18H,7-9H2,1-2H3
• chave InChI: BCSIRYFYAKLJDK-UHFFFAOYSA-N

Descrição

Aplicação

PDI inhibitor 16F16 has been used to inhibit PDI (protein disulfide isomerase) function to examine the functional conservation of PDIs in human embryonic kidney cells.

PDI inhibitor 16F16 may be used in protein disulfide isomerase-mediated cell signaling studies.

Ações bioquímicas/fisiológicas

16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation.

Protein disulfide isomerase (PDI) inhibitor; suppresses apoptosis induced by misfolded proteins

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable