H5915
2,3-Bis(4-hydroxyphenyl)propionitrile
≥98% (HPLC)
Sinônimo(s):
DPN, Diarylpropionitrile, SC-4473
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About This Item
Fórmula empírica (Notação de Hill):
C15H13NO2
Número CAS:
Peso molecular:
239.27
Número MDL:
Código UNSPSC:
51111800
ID de substância PubChem:
NACRES:
NA.77
Produtos recomendados
esterilidade
non-sterile
Nível de qualidade
Ensaio
≥98% (HPLC)
Formulário
powder
condição de armazenamento
desiccated
cor
white to beige
solubilidade
DMSO: 10 mg/mL, clear
Condições de expedição
ambient
temperatura de armazenamento
−20°C
cadeia de caracteres SMILES
Oc1ccc(CC(C#N)c2ccc(O)cc2)cc1
InChI
1S/C15H13NO2/c16-10-13(12-3-7-15(18)8-4-12)9-11-1-5-14(17)6-2-11/h1-8,13,17-18H,9H2
chave InChI
GHZHWDWADLAOIQ-UHFFFAOYSA-N
Ações bioquímicas/fisiológicas
2,3-Bis(4-hydroxyphenyl)-propionitrile (Diarylprepionitrile, DPN) is an ERβ-selective agonist; IC50 = 15nM. DPN protects WT and ARKO mice and significantly decreases IL-1β following LPS treatment in young adult-derived microglia. PPT (Cat. No.H6036, ERa agonist) enhances cell proliferation, while DPN inhibits it. PPT increases Bcl-2 expression, while DPN decreases it. DPN also elevates Bax expression. DPN induces a dose-dependent increase on vitellogenin synthesis. PPT and DPN are effective in dynamically, but differentially regulating intracellular calcium signaling in hippocampal neurons. DPN is more efficacious than PPT in potentiating a physiological concentration of glutamate-induced intracellular Ca2+ rise in these neurons. DPN prevents the development of prostatic hyperplasia and inflammation in testosterone-treated LuRKO mice.
Características e benefícios
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Aquatic Acute 1 - Eye Irrit. 2
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
dust mask type N95 (US), Eyeshields, Gloves
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