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SML0909

Sigma-Aldrich

Nefopam hydrochloride

≥98% (HPLC)

Sinônimo(s):

3,4,5,6-Tetrahydro-5-methyl-1-phenyl-1H-2,5-benzoxazocine hydrochloride, 5-Methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f]-2,5-oxazocine hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C17H19NO · HCl
Número CAS:
23327-57-3
Peso molecular:
289.80
Número CE:
245-585-5
Número MDL:
MFCD00012750
Código UNSPSC:
12352200
ID de substância PubChem:
329825616
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

powder

condição de armazenamento

desiccated

cor

white to beige

pf

260 °C (dec.) (lit.)

solubilidade

H2O: 5 mg/mL, clear

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cl.CN1CCOC(c2ccccc2)c3ccccc3C1

InChI

1S/C17H19NO.ClH/c1-18-11-12-19-17(14-7-3-2-4-8-14)16-10-6-5-9-15(16)13-18;/h2-10,17H,11-13H2,1H3;1H

chave InChI

CNNVSINJDJNHQK-UHFFFAOYSA-N

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Aplicação

Nefopam hydrochloride has been used as a standard for the quantitative determination of tramadol by gas chromatography–mass spectrometry (GC/MS).

Ações bioquímicas/fisiológicas

Nefopam is a centrally-acting analgesic drug of the benzoxazocine chemical class. Nefopam is a non-opioid, but has a potentiating effect on morphine and other opioids. Its mechanism of action is not certain, but may involve its action as a dopamine/serotonin/norepinephrine reuptake inhibitor.

Características e benefícios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301 + H311 + H331

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
014M4717V

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Pesquise por COA

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F Lamazou et al.
Gynecologie, obstetrique & fertilite, 38(4), 278-282 (2010-04-07)
We report the case of a 21-year-old pregnant women (36 WA) presenting intensive headaches and visual disturbances. Those sellar compression symptoms have made us suppose the diagnosis of autoimmune hypophysitis. MRI has confirmed the typical aspect of symmetric enlargement of
G Chanques et al.
British journal of anaesthesia, 106(3), 336-343 (2011-01-06)
Pain management is challenging in intensive care unit (ICU) patients. The analgesic efficacy, tolerance, and haemodynamic effects of nefopam have never been described in critically ill patients. In consecutive medical-surgical ICU patients who received 20 mg of nefopam i.v. over
Deborah E Kerr et al.
Emergency medicine journal : EMJ, 27(5), 407-408 (2010-04-03)
Nefopam hydrochloride (Acupan) is a potent non-opioid analgesic widely used for the relief of moderate to severe postoperative pain. The drug is generally well tolerated, but it has a broad spectrum of side effects including tachycardia, sweating, nausea, seizures and
Xiaodong Sun et al.
Chirality, 31(2), 118-126 (2019-01-05)
In this work, a new capillary electrokinetic chromatography (EKC) approach using ethanediamine-bonded poly (glycidyl methacrylate) (Ami-PGMA) microspheres as pseudostationary phases (PSPs) for enantioseparation with a polysaccharide, chondroitin sulfate E (CSE), as the chiral selector. The CSE@Ami-PGMA EKC system was applied
Mirosław Czuczwar et al.
Pharmacological reports : PR, 63(3), 690-696 (2011-08-23)
Nefopam is a centrally acting non-opioid analgesic with a mechanism of action that is not completely understood. Adverse effects associated with the therapeutic use and overdose of nefopam are mainly associated with the central nervous system, such as hallucinations, cerebral
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