SML0120
Perhexiline maleate salt
≥98% (HPLC)
Sinônimo(s):
2-(2,2-Dicyclohexylethyl)piperidine
Faça loginpara ver os preços organizacionais e de contrato
About This Item
Fórmula empírica (Notação de Hill):
C19H35N · C4H4O4
Número CAS:
Peso molecular:
393.56
Número CE:
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
NACRES:
NA.25
Produtos recomendados
Nível de qualidade
Ensaio
≥98% (HPLC)
Formulário
powder
cor
white to tan
solubilidade
DMSO: ≥5 mg/mL
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
OC(=O)\C=C/C(O)=O.C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3
InChI
1S/C19H35N.C4H4O4/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18;5-3(6)1-2-4(7)8/h16-20H,1-15H2;1-2H,(H,5,6)(H,7,8)/b;2-1-
chave InChI
JDZOTSLZMQDFLG-BTJKTKAUSA-N
Informações sobre genes
human ... CPT1B(1375) , CPT2(1376) , MTOR(2475)
Procurando produtos similares? Visita Guia de comparação de produtos
Categorias relacionadas
Descrição geral
Perhexiline maleate regulates coronary vasodilatation and blocks exercise-induced tachycardia. It is used to treat angina pectoris and variant angina. Perhexiline maleate functions as a cardiac metabolic agent. It is associated with peripheral neuropathy, high intracranial pressure with papilledema and proximal myopathy.
Aplicação
Perhexiline maleate salt has been used as a stock for worm lifespan assay. It has also been used to block fatty acid oxidation.
Perhexiline maleate salt has been used to block fatty acid oxidation. It has also been used as 5′ adenosine monophosphate-activated protein kinase (AMPK) activator and in worm lifespan assay.
Ações bioquímicas/fisiológicas
Anti-anginal metabolic modulator; carnitine palmitoyltransferase inhibitor
Perhexiline maleate is an anti-anginal metabolic modulator. It inhibits the mitochondrial enzyme carnitine palmitoyltransferase CPT-1 and to a lesser extent CPT-2. This causes a shift in myocardial substrate utilisation from long chain fatty acids to carbohydrates, resulting in increased glucose and lactate utilization and increased ATP production for the same O2 consumption as before and consequently increases myocardial efficiency. Perhexiline maleate was also recently found to inhibit the activity of mTORC1.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Escolha uma das versões mais recentes:
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Os clientes também visualizaram
[Amphiphilic cationic drug myopathy, drug-induced lysosomal storage lipidosis].
T Kumamoto
Ryoikibetsu shokogun shirizu, (36)(36), 263-266 (2001-10-13)
Ryuichiro Yamamoto et al.
Journal of bone and mineral metabolism, 31(1), 26-33 (2012-09-27)
Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder characterized by progressive heterotopic ossification. FOP is caused by a gain-of-function mutation in ACVR1 encoding the bone morphogenetic protein type II receptor, ACVR1/ALK2. The mutant receptor causes upregulation of a
Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes
Xu C, et al.
Testing, 25(2), 523-535 (2018)
Harel Gilutz et al.
Therapeutic drug monitoring, 34(2), 227-231 (2012-02-11)
Concomitant treatment with amiodarone and perhsexiline has been considered to be relatively contraindicated because of the hypothetical risk of potentiated adverse effects mediated by additive inhibition of carnitine palmitoyl transferase 1. To study the prevalence of adverse effects associated with
Ryuta Koishi et al.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, 22(3), 343-350 (2002-05-30)
The novel colony-stimulating factor (CSF) inducer leustroducsin B (LSN-B), which was isolated from Streptomyces platensis, has been shown to have potent cytokine-inducing activities in clonal human bone marrow-derived stromal cell line KM-102 and in primary human bone marrow-derived stromal cells.
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica