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Key Documents

Outros documentos

SML0036

Sigma-Aldrich

Procarbazine hydrochloride

≥98% (HPLC)

Sinônimo(s):

N-(1-Methylethyl)-4-[(2-methylhydrazinyl)methyl]benzamide hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C12H19N3O·HCl
Número CAS:
366-70-1
Peso molecular:
257.76
Número CE:
206-678-6
Número MDL:
MFCD00072082
Código UNSPSC:
12352200
ID de substância PubChem:
329825106
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

powder

condição de armazenamento

desiccated

cor

white to tan

solubilidade

DMSO: ≥18 mg/mL

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cl.CNNCc1ccc(cc1)C(=O)NC(C)C

InChI

1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H

chave InChI

DERJYEZSLHIUKF-UHFFFAOYSA-N

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Aplicação

Procarbazine hydrochloride has been used to study its physicochemical property.
Procarbazine, an antineoplastic alkylating agent, may be used to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an anticancer agent. It may be used to study new combination of anticancer drugs.

Ações bioquímicas/fisiológicas

Procarbazine is an antineoplastic alkylating agent widely used in cancer chemotherapy in combination with other compounds. It has multiple mechanisms of action. Procarbazine inhibits protein, RNA and DNA synthesis in addition to being an alkylating agent.
Procarbazine is metabolized to azoprocarbazine either by cytochrome P450 enzyme and monoamine oxidase in an NADPH (nicotinamide adenine diphosphate) dependent or independent manner. It is considered neurotoxic. Procarbazine is used in combination with therapy for treating Hodgkin′s disease.

Pictogramas

Exclamation markHealth hazard
GHS07,GHS08

Palavra indicadora

Danger

Declarações de precaução

P201 - P301 + P312 + P330 - P308 + P313

Classificações de perigo

Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Repr. 1A

Código de classe de armazenamento

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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To treat patients with different concurrent cancers, including lympho- and myeloproliferative neoplasms, is a difficult task. The paper presents the experience in successfully treating lymphogranulomatosis occurring in a female patient with chronic myeloid leukemia (CML). A combination of the BEACOPP-14
Fourteenth biannual report of the Cochrane Haematological Malignancies Group--focus on autologous stem cell transplantation in hematological malignancies.
Michaela Rancea et al.
Journal of the National Cancer Institute, 104(14), NP-NP (2012-07-25)
eIF2alpha phosphorylation is pathognomonic for immunogenic cell death
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Cell Death and Differentiation, 1-1 (2018)
Eighth Annual Report on Carcinogens, 181-181 (1999)
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Cancer chemotherapy and pharmacology, 71(2), 511-521 (2012-12-12)
Glioblastoma (GBM) is one of the worst cancers in terms of prognosis. Standard therapy consists of resection with concomitant chemoradiotherapy. Resistance to nimustine hydrochloride (ACNU), an alkylating agent, has been linked to methylguanine DNA methyltransferase (MGMT). Daily administration of procarbazine
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