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SMB00461

Sigma-Aldrich

Harmine hydrochloride

≥98% (HPLC)

Sinônimo(s):

7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C13H12N2O · HCl
Número CAS:
343-27-1
Peso molecular:
248.71
Número CE:
206-443-8
Número MDL:
MFCD00012641
Código UNSPSC:
12352205
ID de substância PubChem:
329825025
NACRES:
NA.25

Nível de qualidade

200

Ensaio

≥98% (HPLC)

forma

powder

aplicação(ões)

metabolomics
vitamins, nutraceuticals, and natural products

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cl.COc1ccc2c(c1)[nH]c3c(C)nccc23

InChI

1S/C13H12N2O.ClH/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13;/h3-7,15H,1-2H3;1H

chave InChI

VNPLYCKZIUTKJM-UHFFFAOYSA-N

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Categorias relacionadas

Descrição geral

Harmine hydrochloride is an alkaloid found in Peganum harmala.

Ações bioquímicas/fisiológicas

CNS stimulant.
Harmine hydrochloride has been considered for treatment of cancer and cerebral diseases and is a known CNS stimulant.

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palavra indicadora

Warning

Frases de perigo

H302 + H312 + H332,H351

Classificações de perigo

Acute Tox. 4 Oral - Carc. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Stephanie F Bellmaine et al.
eLife, 6 (2017-09-09)
Genetic analysis has revealed that the dual specificity protein kinase DYRK1A has multiple roles in the development of the central nervous system. Increased DYRK1A gene dosage, such as occurs in Down syndrome, is known to affect neural progenitor cell differentiation
Xiuyun Li et al.
Frontiers in microbiology, 10, 2295-2295 (2019-11-22)
Several studies have demonstrated the significant antiviral, antimicrobial, antiplasmodial, antioxidative, antifungal, antimutagenic, and antitumor properties of harmine hydrochloride (HMH). The main objective of the present study was to investigate the antifungal effects and underlying mechanisms of HMH when combined with
Michael Tarpley et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 162, 105821-105821 (2021-03-31)
DYRK1A (dual-specificity tyrosine phosphorylation-regulated kinase 1a) is highly expressed in glioma, an aggressive brain tumor, and has been proposed as a therapeutic target for cancer. In the current study, we have used an optimized and validated time-resolved fluorescence energy transfer
Elisangela G Cata-Preta et al.
Frontiers in pharmacology, 9, 561-561 (2018-06-14)
Ayahuasca is a hallucinogenic beverage produced from the decoction of Banisteriopsis caapi (Bc) and Psychotria viridis (Pv), β-carboline- and N,N-dimethyltryptamine(DMT)-containing plants, respectively. Accumulating evidence suggests that ayahuasca may have therapeutic effects on ethanol abuse. It is not known, however, whether
Marlaina R Stocco et al.
Molecular neurobiology, 57(11), 4608-4621 (2020-08-08)
CYP2D6 metabolically inactivates several neurotoxins, including beta-carbolines, which are implicated in neurodegenerative diseases. Variation in CYP2D6 within the brain may alter local inactivation of neurotoxic beta-carbolines, thereby influencing neurotoxicity. The beta-carboline harmine, which induces hypothermia and tremor, is metabolized by
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