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G0424

Sigma-Aldrich

Corilagin

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About This Item

Fórmula empírica (Notação de Hill):
C27H22O18
Número CAS:
23094-69-1
Peso molecular:
634.45
Número MDL:
MFCD00238565
Código UNSPSC:
12352205
ID de substância PubChem:
329799812
NACRES:
NA.25

Ensaio

≥98% (HPLC)

Nível de qualidade

200

Formulário

powder

solubilidade

H2O: 1 mg/mL, clear, colorless

aplicação(ões)

metabolomics
vitamins, nutraceuticals, and natural products

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

O[C@@H]1[C@H]2COC(=O)c3cc(O)c(O)c(O)c3-c4c(O)c(O)c(O)cc4C(=O)O[C@@H]1[C@@H](O)[C@@H](O2)OC(=O)c5cc(O)c(O)c(O)c5

InChI

1S/C27H22O18/c28-9-1-6(2-10(29)16(9)32)24(39)45-27-22(38)23-19(35)13(43-27)5-42-25(40)7-3-11(30)17(33)20(36)14(7)15-8(26(41)44-23)4-12(31)18(34)21(15)37/h1-4,13,19,22-23,27-38H,5H2/t13-,19-,22-,23+,27+/m1/s1

chave InChI

TUSDEZXZIZRFGC-XIGLUPEJSA-N

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Descrição geral

Corilagin is a polyphenolic tannic acid and a major bioactive compound present in various plant species. It is an active component of Phyllanthus urinaria and Terminalia catappa L extract used to treat various ailments.

Aplicação

Corilagin has been used to study its inhibitory effect on the growth of breast cancer by inducing apoptosis and autophagy regulated by the release of reactive oxygen species.

Ações bioquímicas/fisiológicas

Corilagin is a polyphenol, specifically a hydrolyzable tannin, found in Traditional Chinese Medicine herbal preparations. It is reported to have anti-inflammatory and anti-tumor activities.
Corilagin shows a variety of biological activities such as anti-inflammatory, anti-viral, anti-oxidant, hepatoprotective, antibacterial, anti-coagulant, hypolipemic and hypotensive. It has been noted to possess anti-tumor, antiproliferative, apoptotic, and autophagic abilities as well. Corilagin has been found to reduce the minimum inhibitory concentration (MIC) of β-lactams against Methicillin-resistant Staphylococcus aureus (MRSA).

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
SLCK9421
SLCB3173
SLBX3743
SLBW8372
SLBW5658

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Penta-O-galloyl-β-D-glucose hydrate ≥96% (HPLC)

Sigma-Aldrich

G7548

Penta-O-galloyl-β-D-glucose hydrate

Ellagic acid hydrate technical grade

Sigma-Aldrich

372749

Ellagic acid hydrate

Ellagic acid analytical standard

Supelco

14668

Ellagic acid

Gallic acid monohydrate ≥99% (HPLC)

Sigma-Aldrich

27645

Gallic acid monohydrate

Ácido gálico 97.5-102.5% (titration)

Sigma-Aldrich

G7384

Ácido gálico

Tannic acid ACS reagent

Sigma-Aldrich

403040

Tannic acid

M Shimizu et al.
Antimicrobial agents and chemotherapy, 45(11), 3198-3201 (2001-10-16)
We found that an extract of Arctostaphylos uva-ursi markedly reduced the MICs of beta-lactam antibiotics, such as oxacillin and cefmetazole, against methicillin-resistant Staphylococcus aureus. We isolated the effective compound and identified it as corilagin. Corilagin reduced the MICs of various
K Nagendra Prasad et al.
Journal of pharmaceutical and biomedical analysis, 51(2), 471-477 (2009-04-07)
The health benefits of fruits acting against chronic diseases are ascribed to their antioxidant activities which are mainly responsible due to the presence of phenolic compounds. The use of ultra-high-pressure-assisted extraction (UHPE) has shown great advantages for the extraction of
Xiaoyu Zhao et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(22), 3137-3140 (2012-03-02)
To establish a RP-HPLC method for the determination of four acids compounds including gallic acid, protocatechuic acid, corilagin and ellagic acid in Erodium Stephanianum. The RP-HPLC separation was performed on an Agilent TC-C18 analytical column (4.6 mm x 250 mm
Nuchanart Rangkadilok et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 45(2), 328-336 (2006-10-20)
The protective effects of fruits and vegetables against chronic diseases have been attributed to the antioxidant properties of some secondary metabolites present in these foods. Plant polyphenols have been reported to exhibit bioactive properties, and in particular antioxidant activities. Longan
Luoqi Jia et al.
BMC complementary and alternative medicine, 13, 33-33 (2013-02-16)
Phyllanthus niruri L. is a well-known hepatoprotective and antiviral medicinal herb. Recently, we identified Corilagin as a major active component with anti-tumor activity in this herbal medicine. Corilagin is a member of the tannin family that has been discovered in
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