SAB5900206

Alpaca Anti-EGFR, recombinant single domain Antibody

recombinant Alpaca (VHH) Nano antibody

• Código UNSPSC: 12352203

Propriedades

• fonte biológica: alpaca
• Nível de qualidade: 100
• recombinante: expressed in (E. coli)
• conjugado: unconjugated
• forma do anticorpo: (Affinity purified VHH antibody)
• clone: EB61, monoclonal
• Ensaio: >95% (SDS-PAGE)
• forma: lyophilized solid
• peso molecular: 14.4 kDa; ~15-18 kDa (SDS PAGE under reducing condition)
• purificado por: affinity chromatography (purified via Ni-charged resin)
• reatividade de espécies: human
• concentração: 1 mg/mL
• técnica(s): ELISA: 1:1000-1:25000; immunofluorescence: 1:200-1:600; immunohistochemistry: 1:200-1:600
• cor: colorless
• pH: ( in PBS, pH 7.4)
• Isotipo: VHH
• nº de adesão de ID de proteína: AAI18666.1
• nº de adesão UniProt: P00533
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... EGFR(1956)

Descrição

Descrição geral

EGFR is a transmembrane glycoprotein that is a member of a family of protein tyrosine kinases crucial in maintaining a normal balance in cell growth and development. Growth factor receptors are involved not only in promoting the proliferation of normal cells but also in the aberrant growth of many types of human tumors. Over-expression of the EGFR gene occurs in carcinomas with and without gene amplification. EGFR and erbB-2 are particularly important in breast cancer because increased production or activation has been associated with poor prognosis. EGFR belongs to a family of growth factor receptors, which also includes ErbB-2/HER-2/neu, ErbB-3/HER-3/neu and ErbB-4/HER-4neu. EGFR can heterodimerize with each of the members of this family.

Especificidade

Human Epidermal Growth Factor Receptor 1 (HER1/EGFR)

Imunogênio

Recombinant human EGFR (Leu25-Ser645) protein

Aplicação

ELISA, IHC,IF

Embalagem

50 µg per vial / 100 µg per vial

forma física

Purified VHH protein in buffer containing 25 mM TAPS pH8.5, 500 mM NaCl, 5 mM EDTA

Reconstituição

Reconstitute the lyophilized protein with sterile deionized water or with 50% glycerol (ACS grade or better) to a stock solution of 1 mg/mL. Solubilize for 30 to 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.

Armazenamento e estabilidade

Stable for 1 years at 4°C from date of receipt.

Outras notas

Storage at 4°C; Do not freeze.

Informações de segurança

• Código de classe de armazenamento: 12 - Non Combustible Liquids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable