S8688

SR 59230A

≥98% (HPLC), powder, β3-Adrenoceptor antagonist

• Sinônimo(s): 3-(2-Ethylphenoxy)-1-[[(1S)-1,2,3,4-tetrahydronaphth-1-yl]amino]-(2S)-2-propanol oxalate salt
• Fórmula empírica (Notação de Hill): C₂₁H₂₇NO₂ · C₂H₂O₄
• Número CAS: 174689-39-5
• Peso molecular: 415.48
• Número MDL: MFCD00940163
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278715
• NACRES: NA.77

Propriedades

• Nome do produto: SR 59230A, ≥98% (HPLC), powder
• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white
• solubilidade: DMSO: >10 mg/mL; H₂O: insoluble
• originador: Sanofi Aventis
• cadeia de caracteres SMILES: OC(=O)C(O)=O.CCc1ccccc1OC[C@@H](O)CN[C@H]2CCCc3ccccc23
• InChI: 1S/C21H27NO2.C2H2O4/c1-2-16-8-4-6-13-21(16)24-15-18(23)14-22-20-12-7-10-17-9-3-5-11-19(17)20;3-1(4)2(5)6/h3-6,8-9,11,13,18,20,22-23H,2,7,10,12,14-15H2,1H3;(H,3,4)(H,5,6)/t18-,20-;/m0./s1
• chave InChI: XTBQNQMNFXNGLR-MKSBGGEFSA-N
• Informações sobre genes: human ... ADRB3(155)

Descrição

Aplicação

SR 59230A was used in the identification of β-adrenoceptors in rat aorta.³ It was tested as a potential therapeutic agent in improving cardiac function in rat model of heart failure.⁴

Ações bioquímicas/fisiológicas

SR 59230A is a β3-adrenoceptor antagonist. It has high affinity for the β3 adrenoceptors occurring in human gut that affect the function of human colonic circular smooth muscle.¹ It is reported that SR 59230A inhibits the Kir2.1-2.3 cardiac potassium channels.²

Características e benefícios

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)