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S3065

Sigma-Aldrich

SC 19220

≥98% (HPLC), solid

Sinônimo(s):

2-Acetylhydrazide 10(11H)-carboxylic acid, 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid

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About This Item

Fórmula empírica (Notação de Hill):
C16H14N3O3Cl
Número CAS:
19395-87-0
Peso molecular:
331.75
Número MDL:
MFCD02259329
Código UNSPSC:
12352200
ID de substância PubChem:
24278701
NACRES:
NA.77

Ensaio

≥98% (HPLC)

Formulário

solid

cor

white

pf

190-191 °C (lit.)

solubilidade

DMSO: soluble 10 mg/mL
H2O: insoluble

cadeia de caracteres SMILES

CC(=O)NNC(=O)N1Cc2ccccc2Oc3ccc(Cl)cc13

InChI

1S/C16H14ClN3O3/c1-10(21)18-19-16(22)20-9-11-4-2-3-5-14(11)23-15-7-6-12(17)8-13(15)20/h2-8H,9H2,1H3,(H,18,21)(H,19,22)

chave InChI

KNURFLJTOUGOOQ-UHFFFAOYSA-N

Informações sobre genes

human ... PTGER1(5731)
rat ... Ptger1(25637)

Aplicação

SC 19220 was used to study the role of prostaglandin E2 in oxygen-glucose deprivation-induced neurotoxicity and preconditioning-induced neuroprotection in rat cortical cultures.

Ações bioquímicas/fisiológicas

EP1 Prostanoid receptor antagonist
SC 19220 is a competitive antagonist of prostaglandin E receptors. It competes with PGE2 in regulating vesicourethral motility and increases the bladder capacity of rats. It inhibits the contraction of smooth muscles in response to prostaglandins E2 and F2α. SC 19220 also inhibits the formation of osteoclasts induced by vitamin D3, parathyroid hormone, IL-11 and IL-6.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
125K4609V
125K46093
125K46092
125K46091
125K4609

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K Fushimi et al.
Osteoarthritis and cartilage, 12(11), 895-903 (2004-10-27)
Calpains are known as Ca(2+)-dependent intracellular neutral cysteine proteases. However, m-calpain is detected in synovial fluid of arthritic joints and is shown to possess the proteoglycanase activity in vitro. The mechanism of m-calpain release into the extracellular spaces during arthritis
J B Farmer et al.
British journal of pharmacology, 52(4), 559-565 (1974-12-01)
1 The effects of the prostaglandin synthetase inhibitor, indomethacin and the prostaglandin antagonist SC-19220 (1-acetyl-2-[8-chloro-10,11-dihydrodibenz (b,f) (1,4)oxazepine-10-carbonyl] hydrazine), were examined on the tone of the guinea-pig isolated tracheal preparation and on the responses of the preparation to prostaglandin F(2alpha), arachidonic
Micaela Zonta et al.
The Journal of physiology, 553(Pt 2), 407-414 (2003-09-23)
The synaptic release of glutamate evokes in astrocytes periodic increases in [Ca2+]i, due to the activation of metabotropic glutamate receptors (mGluRs). The frequency of these [Ca2+]i oscillations is controlled by the level of neuronal activity, indicating that they represent a
Vikram Jadhav et al.
Stroke, 40(1), 261-269 (2008-10-25)
Prostaglandin E(2) (PGE(2)) modulates autonomic transmission in the peripheral circulation. We investigated the role of endogenous PGE(2) and its presynaptic EP(1) receptor subtype in modulating the autonomic neurotransmission in cerebral vasculature. The standard in vitro tissue-bath technique was used for
Toshiyuki Tsujisawa et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 20(1), 15-22 (2004-12-28)
We examined the direct effect of SC-19220, an EP1 prostaglandin (PG) E2 receptor antagonist, on osteoclastogenesis induced by RANK/RANKL signaling in mouse cell cultures. We found that SC-19220 inhibited RANKL-induced osteoclastogenesis by suppression of the RANK/RANKL signaling pathway in osteoclast
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