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B3023

Sigma-Aldrich

Bumetanide

≥98% (TLC), powder, Na⁺/K⁺/Cl⁻ cotransporter inhibitor

Sinônimo(s):

3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid

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About This Item

Fórmula empírica (Notação de Hill):
C17H20N2O5S
Número CAS:
28395-03-1
Peso molecular:
364.42
Número CE:
249-004-6
Número MDL:
MFCD00078949
Código UNSPSC:
12352200
ID de substância PubChem:
24278265
NACRES:
NA.77

Nome do produto

Bumetanide, ≥98%

Ensaio

≥98%

Formulário

powder

originador

Roche

cadeia de caracteres SMILES

CCCCNc1cc(cc(c1Oc2ccccc2)S(N)(=O)=O)C(O)=O

InChI

1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23)

chave InChI

MAEIEVLCKWDQJH-UHFFFAOYSA-N

Informações sobre genes

human ... SLC12A1(6557)

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Ações bioquímicas/fisiológicas

Inhibitor of Na+/K+/Cl- cotransporter.

Características e benefícios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
BCCD9810
BCBW8646
BCBR5487V
BCBR5487
BCBP5916V

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Sigma-Aldrich

SML1813

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S0859 ≥98% (HPLC)

Sigma-Aldrich

SML0638

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Furosemide solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Supelco

F-005

Furosemide solution

Ouabaína European Pharmacopoeia (EP) Reference Standard

O0200000

Ouabaína

Bacopaside II analytical standard

Supelco

44698

Bacopaside II

Mark H Pitcher et al.
The journal of pain : official journal of the American Pain Society, 14(1), 57-65 (2012-12-04)
Stimulation of peripheral nociceptors results in increased c-Fos labeling in spinal cord regions associated with nociceptive processing. Accordingly, intracolonic capsaicin, which generates robust secondary (referred) allodynia on the abdomen of mice, also causes an increased spinal c-Fos labeling. In naïve
Wolfgang Löscher et al.
Neuropharmacology, 69, 62-74 (2012-06-19)
In cortical and hippocampal neurons, cation-chloride cotransporters (CCCs) control the reversal potential (EGABA) of GABAA receptor-mediated current and voltage responses and, consequently, they modulate the efficacy of GABAergic inhibition. Two members of the CCC family, KCC2 (the major neuron-specific K-Cl
Ernesto Vargas et al.
The Journal of physiology, 591(1), 57-65 (2012-09-26)
The expression of Na(+)-K(+)-2Cl(-) cotransporter (NKCC1) is responsible for high intracellular Cl(-) resulting in the excitatory action of GABA(A) receptor activation in the developing brain. Giant depolarizing potentials (GDPs) are spontaneous network oscillations that involve GABA(A) receptors and are thought
Jiajie Shan et al.
The Journal of physiology, 590(21), 5273-5297 (2012-07-11)
Anion and fluid secretion are both defective in cystic fibrosis (CF); however, the transport mechanisms are not well understood. In this study, Cl(-) and HCO(3)(-) secretion was measured using genetically matched CF transmembrane conductance regulator (CFTR)-deficient and CFTR-expressing cell lines
Jun Wang et al.
Journal of neuroinflammation, 19(1), 91-91 (2022-04-14)
The mechanisms underlying dysfunction of choroid plexus (ChP) blood-cerebrospinal fluid (CSF) barrier and lymphocyte invasion in neuroinflammatory responses to stroke are not well understood. In this study, we investigated whether stroke damaged the blood-CSF barrier integrity due to dysregulation of
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