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Key Documents

RAB0817

Sigma-Aldrich

Mouse Ins1 / Insulin-1 ELISA Kit

for serum, plasma and cell culture supernatants

Sinônimo(s):

Insulin

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About This Item

Código UNSPSC:
41116158
NACRES:
NA.32

reatividade de espécies

mouse

embalagem

kit of 96 wells (12 strips x 8 wells)

técnica(s)

ELISA: suitable

entrada

sample type plasma
sample type serum
sample type cell culture supernatant(s)

assay range

inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 5 μIU/mL
standard curve range: 6.25-400 μIU/ml

método de detecção

colorimetric

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

Informações sobre genes

mouse ... Ins1(16333)

Descrição geral

The antibody pair provided in this kit recognizes Mouse Insulin 1.

Aplicação

Mouse Ins1 / Insulin-1 ELISA Kit has been used to measure changes in serum insulin in male Sprague-Dawley rats with chemically induced diabetes.
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)

Ações bioquímicas/fisiológicas

Certain organisms such as mice, rat and xenopus possess two non-allelic insulin genes. These genes are Ins1 and Ins2, which are both functional. They encode insulin that is produced in a 1:2 ratio, respectively in the pancreas. The two genes are differentially expressed in mouse. The Ins1 gene maps to mouse chromosome 19 in the telomeric region. The insulin that is synthesized in the pancreas is crucial in maintaining glucose homeostasis. Knockout of Ins-1 and Ins-2 leads to insulin deficient mice with diabetes mellitus, ketoacidosis, liver steatosis and retarded growth.

Outras notas

A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.

Componentes do kit também disponíveis separadamente

Nº do produto
Descrição
SDS
  • RABTMB3ELISA Colorimetric TMB Reagent (HRP Substrate, Item H)SDS
  • RABSTOP3ELISA Stop Solution (Item I)SDS
  • RABELADBELISA 5X Assay/Sample Diluent Buffer B (Item E1)SDS
  • RABELADCELISA 1X Assay/Sample Diluent Buffer C (Item L)SDS
  • RABWASH420X Wash Buffer (Item B)SDS

Pictogramas

Corrosion
GHS05

Palavra indicadora

Warning

Frases de perigo

H290

Declarações de precaução

P234 - P390

Classificações de perigo

Met. Corr. 1

Código de classe de armazenamento

8A - Combustible corrosive hazardous materials

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Phenotypic alterations in insulin-deficient mutant mice.
Duvillie B, et al.
Proceedings of the National Academy of Sciences of the USA, 94(10), 5137-5140 (1997)
Differential expression and imprinting status of Ins1 and Ins2 genes in extraembryonic tissues of laboratory mice.
Deltour L, et al.
Gene expression patterns : GEP, 5(2), 297-300 (2004)
David P Labbé et al.
Nature communications, 10(1), 4358-4358 (2019-09-27)
Systemic metabolic alterations associated with increased consumption of saturated fat and obesity are linked with increased risk of prostate cancer progression and mortality, but the molecular underpinnings of this association are poorly understood. Here, we demonstrate in a murine prostate
Snehal N Chaudhari et al.
Nature chemical biology, 17(1), 20-29 (2020-08-05)
Bariatric surgery, the most effective treatment for obesity and type 2 diabetes, is associated with increased levels of the incretin hormone glucagon-like peptide-1 (GLP-1) and changes in levels of circulating bile acids. The levels of individual bile acids in the
Evaluation of White Sesame Seed Oil on Glucose Control and Biomarkers of Hepatic, Cardiac, and Renal Functions in Male Sprague-Dawley Rats with Chemically Induced Diabetes.
Aslam F, et al.
Journal of Medicinal Food, 20(5), 448-457 (2017)
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