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I2018

Sigma-Aldrich

Monoclonal Anti-Insulin antibody produced in mouse

clone K36AC10, ascites fluid

Sinônimo(s):

Insulin Antibody, Insulin Antibody - Monoclonal Anti-Insulin antibody produced in mouse

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About This Item

Número MDL:
MFCD00164675
Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

mouse

Nível de qualidade

200

conjugado

unconjugated

forma do anticorpo

ascites fluid

tipo de produto de anticorpo

primary antibodies

clone

K36AC10, monoclonal

contém

15 mM sodium azide

reatividade de espécies

feline, human, rat, horse, rabbit, guinea pig, bovine, monkey, sheep, canine, pig

técnica(s)

dot blot: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1,000 using human or animal pancreas
radioimmunoassay: suitable

Isotipo

IgG1

nº de adesão UniProt

P01308

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... INS(3630)

Descrição geral

The antibody reacts specifically against insulin by RIA and immunocytochemistry. It exhibits cross-reactivity with human proinsulin. The antibody binds to insulin with an affinity constant of 8.8 × 109 M-1 in RIA.
The insulin gene is mapped to human chromosome 11p15.5.

Aplicação

Monoclonal Anti-Insulin antibody produced in mouse has been used in immunoblotting assay and ELISA.
Monoclonal Anti-Insulin antibody produced in mouse was used in ELISA-based protein pin array assay to study the interactions between human αB crystalline and insulin. It was used for flow cytometric analysis of rat white blood cells and mast cells.

Ações bioquímicas/fisiológicas

Insulin is a major regulatory hormone important in the metabolic processes, transport of glucose, amino acids and certain ions. It is also involved in the synthesis of nucleic acids and proteins. The biological effects of insulin are mediated by insulin receptor and it integrates multiple major signaling pathways.
Insulin is a major regulatory hormone important in the metabolic processes, transport of glucose, amino acids and certain ions. It is also involved in the synthesis of nucleic acids and proteins. The biological effects of insulin are mediated by insulin receptor and it integrates multiple major signaling pathways. Abnormal insulin secretion or function leads to diabetes mellitus, obesity and other carbohydrate metabolism disorders. Insulin is known to stimulate cell division.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Sandra K Szlapinski et al.
The Journal of physiology, 597(16), 4237-4250 (2019-06-18)
Pancreatic β-cell dysfunction is hypothesized to be the significant determinant of gestational diabetes pathogenesis, however pancreatic samples from patients are scarce. This study reports a novel mouse model of gestational glucose intolerance in pregnancy, originating from previous nutrition restriction in
Lechago J and Shah I
Atlas of Diagnostic Immunochemistry null
Islet amyloid develops diffusely throughout the pancreas before becoming severe and replacing endocrine cells.
Wang F, et al.
Diabetes, 50(11), 2514-2520 (2001)
J Matthew Rhett et al.
Journal of diabetes research, 2016, 7262680-7262680 (2016-01-21)
Total pancreatectomy and islet autotransplantation is a cutting-edge technique to treat chronic pancreatitis and postoperative diabetes. A major obstacle has been low islet cell survival due largely to the innate inflammatory response. Connexin43 (Cx43) channels play a key role in
Proinsulin-specific monoclonal antibodies. Immunocytochemical application as beta-cell markers and as probes for conversion.
O D Madsen
Diabetes, 36(10), 1203-1211 (1987-10-01)
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