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P9271

Sigma-Aldrich

α-(4-Pyridyl N-oxide)-N-tert-butylnitrone

~95%

Sinônimo(s):

N-(4-Pyridylmethylene)-tert-butylamine N,N′-dioxide, N-tert-Butyl-α-(4-pyridyl)nitrone N′-oxide, POBN

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About This Item

Fórmula empírica (Notação de Hill):
C10H14N2O2
Número CAS:
66893-81-0
Peso molecular:
194.23
Beilstein:
1453764
Número CE:
266-512-3
Número MDL:
MFCD00041022
Código UNSPSC:
12352100
ID de substância PubChem:
24899024
NACRES:
NA.22

Ensaio

~95%

Formulário

crystals

pf

183-185 °C (lit.)

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

CC(C)(C)\[N+]([O-])=C/c1cc[n+]([O-])cc1

InChI

1S/C10H14N2O2/c1-10(2,3)12(14)8-9-4-6-11(13)7-5-9/h4-8H,1-3H3/b12-8+

chave InChI

RNRMWTCECDHNQU-XYOKQWHBSA-N

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Aplicação

Spin trap reagent used to measure ethanol oxidation to 1-hydroxyethyl radical (HER) which can bind to protein. Has also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide. The formation of hydroxyl radical in chondrocytes and cartilage has been detected using POBN.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
BGBB3366
BGBB0603
MKBB7680
126K3738
100K3674

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Tuberculosis has re-emerged as a worldwide threat, which has motivated the development of new drugs. The antituberculosis complex Na3[Fe(CN)5(isoniazid)] (IQG607) in particular is of interest on account of its ability to overcome resistance. IQG607 has the potential for redox-mediated-activation, in
Thiago C Genaro-Mattos et al.
Biochemistry, 54(18), 2841-2850 (2015-04-14)
Lipid peroxidation is a well-known process that has been implicated in many diseases. Recent evidence has shown that mitochondrial cholesterol levels are increased under specific conditions, making it an important target for peroxidation inside the mitochondria. Cholesterol peroxidation generates, as

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