P9115

Protein Kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt

≥90% (HPLC), lyophilized powder

• Fórmula empírica (Notação de Hill): C₅₃H₉₈N₂₀O₁₂ · C₂HF₃O₂
• Peso molecular: 1321.50
• Número MDL: MFCD03788010
• Código UNSPSC: 12352204
• ID de substância PubChem: 329820342
• NACRES: NA.32

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥90% (HPLC)
• Formulário: lyophilized powder
• solubilidade: H₂O: soluble
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: OC(=O)C(F)(F)F.CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O
• InChI: 1S/C53H100N20O12.C2HF3O2/c1-6-8-9-10-11-12-13-14-15-16-17-24-39(76)65-29-40(77)69-35(22-19-26-63-52(58)59)48(83)73-43(33(5)74)50(85)66-30-41(78)68-34(21-18-25-62-51(56)57)46(81)70-36(23-20-27-64-53(60)61)47(82)71-37(28-38(54)75)49(84)67-32(4)45(80)72-42(44(55)79)31(3)7-2;3-2(4,5)1(6)7/h31-37,42-43,74H,6-30H2,1-5H3,(H2,54,75)(H2,55,79)(H,65,76)(H,66,85)(H,67,84)(H,68,78)(H,69,77)(H,70,81)(H,71,82)(H,72,80)(H,73,83)(H4,56,57,62)(H4,58,59,63)(H4,60,61,64);(H,6,7)/t31-,32-,33+,34-,35-,36-,37-,42-,43-;/m0./s1
• chave InChI: DBHNUJXUTKVLID-UXBYPZMDSA-N
• Informações sobre genes: human ... PRKACA(5566) ; mouse ... PRKACA(18747) ; rat ... PRKACA(25636)

Descrição

Amino Acid Sequence

Myr-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2

Descrição geral

Protein kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt inhibits the protein kinase cAMP-activated catalytic subunit-α (PRKACA). The gene encoding it is localized on human chromosome 19p13.1.

Aplicação

Protein kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt has been used in cell culture for pharmaceutical inhibition and activation studies.

Ações bioquímicas/fisiológicas

Mutations in the gene encoding protein kinase cAMP-activated catalytic subunit-α (PRKACA) have been associated with Cushing′s syndrome.

Cell permeable cAMP-dependent protein kinase (PKA) inhibitor

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)