P8765

Ammonium pyrrolidinedithiocarbamate

~99%

• Sinônimo(s): 1-Pyrrolidinecarbodithioic acid ammonium salt, APDC, Ammonium pyrrolidinecarbodithioate, PDC, PDTC
• Fórmula linear: C₅H₉NS₂ · NH₃
• Número CAS: 5108-96-3
• Peso molecular: 164.29
• Beilstein: 3730472
• Número CE: 225-834-4
• Número MDL: MFCD00012720
• Código UNSPSC: 12352107
• ID de substância PubChem: 24278658
• NACRES: NA.77

Propriedades

• fonte biológica: microbial
• Ensaio: ~99%
• forma: (powderor powder with lumps)
• pf: 153-155 °C (lit.)
• solubilidade: water: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: N.SC(=S)N1CCCC1
• InChI: 1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
• chave InChI: MDDIUTVUBYEEEM-UHFFFAOYSA-N
• Informações sobre genes: human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846) , RELA(5970)

Descrição

Descrição geral

Ammonium pyrrolidinedithiocarbamate is a nuclear factor κB (NF-κB) inhibitor. It functions as a chelating agent, which allows the preconcentration of trace metals from solution. Pyrrolidinedithiocarbamate (PDTC) has antioxidant properties. It inhibits apoptosis in lymphocytes, neurons and vascular endothelial cells.

Aplicação

Ammonium pyrrolidinedithiocarbamate has been used:

• to inhibit nuclear factor κB (NF-κB) mobilization and TNF (tumor necrosis factor) production in human monocytes
• to reduce neutrophil activity in rats
• to prevent Ca²⁺ influx in adriamycin (ADR)-treated podocytes

to abrogate the microRNA-146a promoter luciferase reporter activity in human brain cells

Ações bioquímicas/fisiológicas

Prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves