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158631

4′-Chloroacetanilide

Name: 4′-Chloroacetanilide
Brand: ALDRICH

97%

Sinônimo(s):

N-(4-Chlorophenyl)acetamide, Acetic acid 4-chloroanilide, NSC 40563, NSC 444

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About This Item

Fórmula linear:

CH₃CONHC₆H₄Cl

Número CAS:

539-03-7

Peso molecular:

169.61

Beilstein:

509638

Número CE:

208-707-8

Número MDL:

MFCD00000612

Código UNSPSC:

12352100

ID de substância PubChem:

24849769

NACRES:

NA.22

Nível de qualidade

100

Ensaio

97%

forma

solid

pf

176-178 °C (lit.)

cadeia de caracteres SMILES

CC(=O)Nc1ccc(Cl)cc1

InChI

1S/C8H8ClNO/c1-6(11)10-8-4-2-7(9)3-5-8/h2-5H,1H3,(H,10,11)

chave InChI

GGUOCFNAWIODMF-UHFFFAOYSA-N

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Categorias relacionadas

Elementos estruturais orgânicos

Descrição geral

4′-Chloroacetanilide is the main impurity present in acetaminophen and has been quantitated by new high-performance liquid chromatography method using a mixed-mode reversed-phase/cation exchange stationary phase.

Aplicação

<ul>
<li><strong>High-performance liquid chromatography (HPLC) method validation:</strong> 4 chloroacetanilide is used as an internal standard for isosorbide dinitrate in the assay of sustained-release tablets or capsules containing nitroglycerin, isosorbide dinitrate, or pentaerythritol tetranitrate by high-performance liquid chromatography (Gelber and Papas, 1983).</li>
</ul>

Pictogramas

GHS07

Palavra indicadora

Warning

Frases de perigo

H315 - H319 - H335

Declarações de precaução

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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On-line reaction monitoring of lithiation of halogen substituted acetanilides via in situ calorimetry, ATR spectroscopy, and endoscopy.

Tamas A Godany et al.

Chimia, 65(4), 253-255 (2011-06-18)

Lithiation of N-(4-chlorophenyl)-pivalamide (NCP) and two additional substituted acetanilides: 4-fluoroacetanilide (4-F) and 4-chloroacetanilide (4-Cl) has been monitored by means of calorimetry, on-line ATR-IR and UV/vis spectroscopy and endoscopy. The combined on-line monitoring revealed the differences between the reaction paths of

Generalized cytochrome P450-mediated oxidation and oxygenation reactions in aromatic substrates with activated N-H, O-H, C-H, or S-H substituents.

L Koymans et al.

Xenobiotica; the fate of foreign compounds in biological systems, 23(6), 633-648 (1993-06-01)

1. The general mechanism of metabolic oxidation of substrates by cytochromes P450 (P450s) appears to consist of sequential one-electron oxidation steps rather than of a single concerted transfer of activated oxygen species from P450 to substrates. 2. In case of

HPLC separation of acetaminophen and its impurities using a mixed-mode reversed-phase/cation exchange stationary phase.

Octavian Călinescu et al.

Journal of chromatographic science, 50(4), 335-342 (2012-03-13)

Determination of acetaminophen and its main impurities: 4-nitrophenol, 4'-chloroacetanilide, as well as 4-aminophenol and its degradation products, p-benzoquinone and hydroquinone has been developed and validated by a new high-performance liquid chromatography method. Chromatographic separation has been obtained on a Hypersil

Development of EPA method 535 for the determination of chloroacetanilide and other acetamide herbicide degradates in drinking water by solid-phase extraction and liquid chromatography/tandem mass spectrometry.

Jody A Shoemaker et al.

Journal of AOAC International, 89(1), 201-209 (2006-03-04)

U.S. Environmental Protection Agency (EPA) Method 535 has been developed in order to provide a method for the analysis of "Alachlor ESA and other acetanilide degradation products," which are listed on EPA's 1998 Drinking Water Contaminant Candidate List. Method 535

Toxicology laboratory analysis and human exposure to p-chloroaniline.

Anthony F Pizon et al.

Clinical toxicology (Philadelphia, Pa.), 47(2), 132-136 (2008-07-09)

p-Chloroaniline is more potent at producing methemoglobin than aniline in animal models. This case highlights the clinical presentation of an inhalation exposure to p-chloroaniline and associated laboratory analysis. An in-vitro study evaluating the metabolism of p-chloroaniline in human hepatocytes was

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