J4455

JSH-23

≥98% (HPLC), solid

• Sinônimo(s): 4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine
• Fórmula empírica (Notação de Hill): C₁₆H₂₀N₂
• Número CAS: 749886-87-1
• Peso molecular: 240.34
• Código UNSPSC: 51111800
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: solid
• condição de armazenamento: protect from light
• cor: off-white to gray-pink
• solubilidade: DMSO: >10 mg/mL
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: N(CCCc2ccccc2)c1c(cc(cc1)C)N
• InChI: 1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
• chave InChI: YMFNPBSZFWXMAD-UHFFFAOYSA-N

Descrição

Aplicação

JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.

Ações bioquímicas/fisiológicas

JSH-23 is an inhibitor of NF-kB nuclear translocation.

JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.

Outras notas

Light and air sensitive.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3