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Key Documents

P6249

Sigma-Aldrich

p53 human

recombinant, expressed in E. coli, buffered aqueous glycerol solution

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.25

fonte biológica

human

Nível de qualidade

200

recombinante

expressed in E. coli

Ensaio

≥90% (SDS-PAGE)

forma

buffered aqueous glycerol solution

nº de adesão UniProt

P04637

aplicação(ões)

genomic analysis

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

Informações sobre genes

human ... TP53(7157)

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Descrição geral

p53 is regulated by MDM2, which acts as a negative regulator of p53 transcription by promoting its degradation by functioning as an E3 ubiquitin ligase which recognizes the N′ terminal transactivation domain.

Aplicação

Useful for the study of postranslational modification of p53, or protein-protein interaction studies.

Ações bioquímicas/fisiológicas

p53 gene is highly conserved and expressed in normal tissues. It is the most commonly mutated gene in human cancer and more then 500 gene mutations have been described in various types of malignancies, hematologic as well as solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells. Thus, p53 plays a vital role in suppressing the development of cancer.

propriedades físicas

GST-tagged, full-length human p53

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Human p53 ELISA Kit for serum, plasma, cell culture supernatant and urine

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RAB0500

Human p53 ELISA Kit

MDM2, HIS tagged human recombinant, expressed in E. coli, ≥80% (SDS-PAGE), buffered aqueous solution

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SRP2095

MDM2, HIS tagged human

ANTI-P53 (S15) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

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SAB1306667

ANTI-P53 (S15) antibody produced in rabbit

Anti-p53 antibody, Mouse monoclonal clone PAb1801, purified from hybridoma cell culture

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P6749

Anti-p53 antibody, Mouse monoclonal

Dania Alarcon-Vargas et al.
Carcinogenesis, 23(4), 541-547 (2002-04-19)
The p53-Mdm2 paradigm represents the best-studied relationship between a tumor suppressor gene which functions as a transcription factor and an oncogene, which functions primarily as an E3 protein ligase. The intimate relationship between these two partners has expanded to include
Se Kyung Lee et al.
PloS one, 10(8), e0124658-e0124658 (2015-08-05)
Overexpression of p53 is the most frequent genetic alteration in breast cancer. Recently, many studies have shown that the expression of mutant p53 differs for each subtype of breast cancer and is associated with different prognoses. In this study, we
Alejandra Ward et al.
BMC cancer, 11, 71-71 (2011-02-18)
Hepatocellular carcinoma (HCC), one of the most common cancers world-wide occurs twice as often in men compared to women. Predisposing conditions such as alcoholism, chronic viral hepatitis, aflatoxin B1 ingestion, and cirrhosis all contribute to the development of HCC. We
Brandon S Sheffield et al.
The American journal of surgical pathology, 39(7), 977-982 (2015-01-31)
A variety of immunohistochemical (IHC) stains have been proposed to mark either benign or malignant mesothelial proliferations. Loss of the p16 tumor suppressor (CDKN2A), through homozygous deletions of 9p21, is a good marker of mesotheliomas but lacks sensitivity. Recent reports
Cristina Muñoz-San Martín et al.
Analytical and bioanalytical chemistry, 412(24), 6177-6188 (2020-01-29)
Proteases are involved in cancer' taking part in immune (dis)regulation, malignant progression and tumour growth. Recently, it has been found that expression levels of one of the members of the serine protease family, trypsin, is upregulated in human cancer cells
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