P5515

Prostaglandin E₁

≥98% (HPLC), powder, vasodilator 

• Sinônimo(s): (11α,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-enoic acid, Alprostadil, PGE₁
• Fórmula empírica (Notação de Hill): C₂₀H₃₄O₅
• Número CAS: 745-65-3
• Peso molecular: 354.48
• Beilstein: 5294062
• Número CE: 212-017-2
• Número MDL: MFCD00077860
• Código UNSPSC: 12352211
• eCl@ss: 42020658
• ID de substância PubChem: 57654538
• NACRES: NA.77

Propriedades

• Nome do produto: Prostaglandin E₁, ≥98% (HPLC), synthetic
• fonte biológica: synthetic
• Nível de qualidade: 200
• Ensaio: ≥98% (HPLC)
• Formulário: (powder to crystals)
• solubilidade: ethanol: 5 mg/mL
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1
• InChI: 1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1
• chave InChI: GMVPRGQOIOIIMI-DWKJAMRDSA-N
• Informações sobre genes: human ... PTGER1(5731) , PTGER2(5732) , PTGIR(5739) ; mouse ... Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219)

Descrição

Aplicação

Prostaglandin E1 has been used:

• as a platelet inhibitor to analyse its effect on autophagy
• in platelet adhesion assay
• to investigate its effect on cAMP production in thyroid glands of normal and growth-retarded mouse in vitro.

Ações bioquímicas/fisiológicas

Prostaglandin E1 (PGE1) is a hormone synthesized from dihomo-γ-linolenic acid (DGLA) by the action of enzyme prostaglandin synthase. It is a vasodilator and activates adenylate cyclase. It is majorly present in human semen and is a potent platelet aggregation inhibitor. PGE1 infusions is effective in treating limb ischemia and peripheral vascular disease. It is unstable and is hydrolyzed to PGA1 in the lungs. Nanoparticle encapsulation of PGE1 is essential for its delivery at the vascular injury site. It elicits vasodilator effects on the retinal artery and vein in central retinal artery occlusion (CRAO). PGE1 and its synthetic analog misoprostol interact with E-prostanoid receptor 4 (EP4) and elicits protection in chronic myelogenous leukemia (CML).

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H301
• Declarações de precaução: P301 + P310 + P330
• Classificações de perigo: Acute Tox. 3 Oral
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Faceshields, Gloves