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P178

Sigma-Aldrich

Pyridoxal phosphate-6-azo(benzene-2,4-disulfonic acid) tetrasodium salt hydrate

solid, ≥98% (HPLC)

Sinônimo(s):

4-[[4-Formyl-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-2-pyridinyl]azo]-1,3-benzenedisulfonic acid tetrasodium salt, PPADS tetrasodium salt hydrate

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About This Item

Fórmula empírica (Notação de Hill):
C14H10N3Na4O12PS2 · xH2O
Número CAS:
192575-19-2
Peso molecular:
599.31 (anhydrous basis)
Número MDL:
MFCD11046026
Código UNSPSC:
12352106
ID de substância PubChem:
24277733
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

solid

cor

red to orange

solubilidade

H2O: >10 mg/mL

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

O.[Na+].[Na+].[Na+].[Na+].Cc1nc(\N=N\c2ccc(cc2S([O-])(=O)=O)S([O-])(=O)=O)c(COP([O-])([O-])=O)c(C=O)c1O

InChI

1S/C14H14N3O12PS2.4Na.H2O/c1-7-13(19)9(5-18)10(6-29-30(20,21)22)14(15-7)17-16-11-3-2-8(31(23,24)25)4-12(11)32(26,27)28;;;;;/h2-5,19H,6H2,1H3,(H2,20,21,22)(H,23,24,25)(H,26,27,28);;;;;1H2/q;4*+1;/p-4/b17-16+;;;;;

chave InChI

JTTDHFFNVGHDLN-YDTRVRFHSA-J

Informações sobre genes

human ... LPAR4(2846) , LTB4R(1241) , P2RX1(5023) , P2RY1(5028) , P2RY10(27334) , P2RY11(5032) , P2RY12(64805) , P2RY13(53829) , P2RY14(9934) , P2RY2(5029) , P2RY4(5030) , P2RY5(10161) , P2RY6(5031) , P2RY8(286530)

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Categorias relacionadas

Ações bioquímicas/fisiológicas

Non-selective P2 purinoceptor antagonist which blocks responses at both pre- and post-junctional sites.

Características e benefícios

This compound is featured on the P2 Receptors: P2X Ion Channel Family and P2 Receptors: P2Y G-Protein Family pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Atenção

Light sensitive

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
065M4620V
122M4602V
030M4615
079K4601
027K4601

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Marian T Namovic et al.
Current protocols in pharmacology, Chapter 9, Unit 9-Unit 9 (2012-06-12)
Adenosine triphosphate (ATP) activates two receptor superfamilies, metabotropic P2Y and ionotropic P2X receptors. The P2X receptors are nonselective cation channels that are widely expressed on excitable cells including neurons, glia, and smooth muscle cells. The protocols in this unit are
G Lambrecht et al.
European journal of pharmacology, 217(2-3), 217-219 (1992-07-07)
We have characterized PPADS (pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid) as a novel antagonist which selectively blocks P2 purinoceptor-mediated responses in rabbit vas deferens at pre- and postjunctional sites. PPADS did not interact with alpha 1-adrenoceptors, muscarinic M2 and M3 receptors, histamine H1 and
Lisa Felix et al.
Cells, 9(1) (2020-01-08)
In the neonate forebrain, network formation is driven by the spontaneous synchronized activity of pyramidal cells and interneurons, consisting of bursts of electrical activity and intracellular Ca2+ oscillations. By employing ratiometric Na+ imaging in tissue slices obtained from animals at
Wenchao Xiong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(23), 4606-4623 (2019-03-25)
Major depressive disorder is the most common mental illness. Mounting evidence indicates that astrocytes play a crucial role in the pathophysiology of depression; however, the underlying molecular mechanisms remain elusive. Compared with other neuronal cell types, astrocytes are enriched for
Oksana Forostyak et al.
Stem cells and development, 22(10), 1506-1521 (2013-01-09)
Human embryonic stem cell-derived neural precursors (hESC NPs) are considered to be a promising tool for cell-based therapy in central nervous system injuries and neurodegenerative diseases. The Ca(2+) ion is an important intracellular messenger essential for the regulation of various

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