C80105

Chrysin

≥96.5% purity, powder

• Sinônimo(s): 5,7-Dihydroxyflavone
• Fórmula empírica (Notação de Hill): C₁₅H₁₀O₄
• Número CAS: 480-40-0
• Peso molecular: 254.24
• Beilstein: 233276
• Número CE: 207-549-7
• Número MDL: MFCD00006834
• Código UNSPSC: 12171500
• ID de substância PubChem: 24893009
• NACRES: NA.47

Propriedades

• Nome do produto: Chrysin, ≥96.5%
• Ensaio: ≥96.5%
• Formulário: powder
• cor: beige
• pf: 284-286 °C (lit.)
• solubilidade: 0.1 M NaOH: 0.008 g/L
• λmax: 348 nm
• aplicação(ões): diagnostic assay manufacturing; hematology; histology
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: Oc1cc(O)c2C(=O)C=C(Oc2c1)c3ccccc3
• InChI: 1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H
• chave InChI: RTIXKCRFFJGDFG-UHFFFAOYSA-N
• Informações sobre genes: human ... CDC2(983) , CDK5(1020) , CDK6(1021) , CYP19A1(1588) , CYP1A2(1544) , GSK3A(2931) ; mouse ... Hexa(15211) , Ptgs2(19225) ; rat ... Gabra2(29706)

Descrição

Aplicação

• Chrysin has been used to study the effect of bioflavonoids on the inhibition of ATP synthase in Escherichia coli.
• It has been used to study the effect of Chrysin on eIF4E (eukaryotic translation initiation factor 4E) expression in AGS cell (human gastric carcinoma cell) line.
• It has been used to study the effect of chrysin on human ovarian cancer cells.

Ações bioquímicas/fisiológicas

Chrysin is a flavonoid and an analog of apigenin. It inhibits aromatase and also suppresses human immunodeficiency virus (HIV) activation in models with latent infection. Chrysin exhibits anti-inflammatory and anti-oxidant effects. This molecule induces apoptosis in various cells, thereby exhibiting cancer chemopreventive activity. Chrysin can modulate the activity of GABAA (Type-A γ-aminobutyric acid) and GABAC receptors, it downregulates expression of PCNA (proliferating cell nuclear antigen), reduces activity of CDK2 (cyclin-dependent kinase 2) and CDK4 and induces p38-MAPK (mitogen-activated protein kinase) activation.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)