Pular para o conteúdo
Merck
Todas as fotos(4)

Documentos

D7321

Sigma-Aldrich

Diosmetin

Sinônimo(s):

3′,5,7-Trihydroxy-4′-methoxyflavone, 4′-Methylluteolin, 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one, Luteolin 4′-methyl ether

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(4)

About This Item

Fórmula empírica (Notação de Hill):
C16H12O6
Número CAS:
520-34-3
Peso molecular:
300.26
Beilstein:
294492
Número CE:
208-291-8
Número MDL:
MFCD00017425
Código UNSPSC:
12352205
ID de substância PubChem:
329798848
NACRES:
NA.25

Ensaio

≥98% (HPLC)

forma

powder

cor

light yellow to yellow

solubilidade

DMSO: 1 mg/mL, clear, faintly yellow to greenish-yellow

aplicação(ões)

metabolomics
vitamins, nutraceuticals, and natural products

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

COc1ccc(cc1O)C2=CC(=O)c3c(O)cc(O)cc3O2

InChI

1S/C16H12O6/c1-21-13-3-2-8(4-10(13)18)14-7-12(20)16-11(19)5-9(17)6-15(16)22-14/h2-7,17-19H,1H3

chave InChI

MBNGWHIJMBWFHU-UHFFFAOYSA-N

Procurando produtos similares? Visita Guia de comparação de produtos

Descrição geral

Diosmetin is a methylated aglycone flavone of diosmin. It is present abundantly in citrus fruits, Olea europaea L. (olive tree) leaves, and in the legume of Acacia farnesiana tree.

Aplicação

Diosmetin has been used to test its protective effects on chronic stress memory and cognitive impairment in mice model.

Ações bioquímicas/fisiológicas

Diosmetin exhibits anti-inflammatory, anti-cancer, antimicrobial, phytoestrogenic, and neuroprotective properties. It displays cytoprotective effects against lipopolysaccharide (LPS)-induced acute lung injury (ALI) by inhibiting nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome and activating nuclear factor erythroid 2–related factor 2 (Nrf2).
Flavonoid from Citrus limon. Antioxidant. Inhibits carcinogen activation by inhibiting the CYP1A1 enzyme.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Os clientes também visualizaram

Slide 1 of 4

1 of 4

Chrysin ≥96.5%

Sigma-Aldrich

C80105

Chrysin

Hesperidin analytical standard

Supelco

50162

Hesperidin

Apigenin ≥97% (TLC), from citrus

Sigma-Aldrich

SMB00702

Apigenin

Hesperidin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1794

Hesperidin

A review on pharmacological and analytical aspects of diosmetin: a concise report.
Patel, et al.
Chinese Journal of Integrative Medicine, 19, 792-800 (2018)
Elham Saghaei et al.
Evidence-based complementary and alternative medicine : eCAM, 2020, 5725361-5725361 (2021-01-09)
In the present experimental study, male NMRI mice were exposed to chronic unpredictable mild stress (CUMS) paradigm for 35 days. Diosmetin (at doses of 10, 20, and 40 mg/kg. i.p.) or diosmetin solvent (normal saline + DMSO, 1 ml/kg; i.p.) was administered 30 min before
Qinmei Liu et al.
Biomolecules & therapeutics, 26(2), 157-166 (2017-04-04)
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a common clinical syndrome of diffuse lung inflammation with high mortality rates and limited therapeutic methods. Diosmetin, an active component from Chinese herbs, has long been noticed because of its antioxidant
Vasilis P Androutsopoulos et al.
The Journal of nutritional biochemistry, 24(2), 496-504 (2012-07-04)
Various types of tumors are known to overexpress enzymes belonging to the CYP1 family of cytochromes P450. The present study aimed to characterize the metabolism and further antiproliferative activity of the natural flavonoid diosmetin in the CYP1-expressing human hepatoma cell
Luigi Quintieri et al.
Biochemical pharmacology, 75(6), 1426-1437 (2008-01-15)
We evaluated the effects of increasing concentrations of the flavonoids salvigenin, diosmetin and luteolin on the in vitro metabolism of midazolam (MDZ), a probe substrate for cytochrome P450 (CYP) 3A enzymes, which is converted into 1'-hydroxy-midazolam (1'-OH-MDZ) and 4-hydroxy-midazolam (4-OH-MDZ)
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica