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PP242 hydrate

≥98% (HPLC), powder

Sinônimo(s):

2-(4-amino-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-1H-indol-5-ol

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About This Item

Fórmula empírica (Notação de Hill):
C16H16N6O · xH2O
Número CAS:
1173019-76-5
Peso molecular:
308.34 (anhydrous basis)
Número MDL:
MFCD12828866
Código UNSPSC:
12352200
ID de substância PubChem:
329819988
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

powder

cor

off-white

solubilidade

DMSO: >10 mg/mL

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

O.CC(C)n1nc(-c2cc3cc(O)ccc3[nH]2)c4c(N)ncnc14

InChI

1S/C16H16N6O.H2O/c1-8(2)22-16-13(15(17)18-7-19-16)14(21-22)12-6-9-5-10(23)3-4-11(9)20-12;/h3-8,20,23H,1-2H3,(H2,17,18,19);1H2

chave InChI

FMDOLJSFPXFBIL-UHFFFAOYSA-N

Aplicação

PP242 hydrate has been used:
  • as a mammalian target of rapamycin (mTOR) inhibitor to study its effects on rat fibroblast mTOR complex 1 and 2 (mTORC1 & 2) signaling
  • as an mTOR inhibitor to treat mouse embryonic fibroblasts (MEF) and cumulus cells (CCs) to study its effects on reactivation of embryonic nucleoli and ribosome biogenesis
  • as a target of rapamycin (TOR) kinase inhibitor for the treatment of Arabidopsis to study its effects against Fusarium graminearum infection

Ações bioquímicas/fisiológicas

PP242 is a potent and selective mTOR inhibitor. PP242 is a first selective inhibitor that targets ATP domain of mTOR.

Características e benefícios

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
065M4605V
041M4628V
021M4622V
069K46016
069K46015

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