O5761

Osteocalcin fragment 1-49 Human

≥94% (HPLC), solid

• Fórmula empírica (Notação de Hill): C₂₆₉H₃₈₁N₆₇O₈₂S₂
• Número CAS: 136461-80-8
• Peso molecular: 5929.43
• Número MDL: MFCD03457847
• Código UNSPSC: 12352200
• NACRES: NA.32

Propriedades

• Ensaio: ≥94% (HPLC)
• forma: solid
• nº de adesão UniProt: P02818
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... BGLAP(632)

Descrição

Amino Acid Sequence

Tyr-Leu-Tyr-Gln-Trp-Leu-Gly-Ala-Pro-Val-Pro-Tyr-Pro-Asp-Pro-Leu-Gla-Pro-Arg-Arg-Gla-Val-Cys-Gla-Leu-Asn-Pro-Asp-Cys-Asp-Glu-Leu-Ala-Asp-His-Ile-Gly-Phe-Gln-Glu-Ala-Tyr-Arg-Arg-Phe-Tyr-Gly-Pro-Val [Disulfide Bridge: 23-29]

Descrição geral

Bone γ-carboxyglutamate protein (BGLAP) or osteocalcin (OCN) is a non-collagenous bone matrix protein expressed by osteoblasts. It possesses a Gla (γ carboxyglutamate) domain. The gene encoding OCN is localized on human chromosome 1q22.

Calcium-binding protein found in dentin and possibly other mineralized tissues.

Aplicação

Human osteocalcin fragment 1-49 has been used for the identification and characterization of glycation adducts on osteocalcin. It has also been used to study its effects on the differentiation of mouse myoblast cell line C2C12.

Ações bioquímicas/fisiológicas

Bone γ-carboxyglutamate protein (BGLAP) regulates osteogenic differentiation of mesenchymal stromal cells. It has a role in bone turnover and mineralization. The protein also has a role in energy metabolism. BGLAP may act as a mediator between glucose metabolism and bone tissue.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable