L2515
Lipoteichoic acid from Staphylococcus aureus
bacterial cell wall polymer
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About This Item
Produtos recomendados
fonte biológica
Staphylococcus aureus
Nível de qualidade
Formulário
lyophilized powder
grupo funcional
phospholipid
tipo de lipídio
polymerizable lipids
Condições de expedição
ambient
temperatura de armazenamento
2-8°C
Categorias relacionadas
Descrição geral
Lipoteichoic acid (LTA) is a linear polymer of phosphodiester-linked glycerol phosphate covalently bound to a lipid. The C2 position on the glycerol-phosphate is usually glycosylated or D-alanylated. LTA is amphipathic due to the presence of the negatively charged backbone of glycerol phosphate and the hydrophobic lipid. The lipid portion is bound hydrophobically to the cell membrane, whereas the polyglycerol phosphate portion extends into the cell wall.
Lipoteichoic acid (LTA) is a teichoic acid attached to a lipid abundant on Gram-positive bacteria cell wall. LTA is a pathogen-associated molecular-patterns (PAMP) recognized by Toll-like receptor 2 (TLR2), This recognition leads to the activation of NF-kB.
Aplicação
Lipoteichoic acid from Staphylococcus aureus has been used:
- to investigate the binding properties of SpHyastatin to lipopolysaccharides and lipoteichoic acid using enzyme-linked immunosorbent assay (ELISA)
- to measure the interleukin (IL-6) produced in splenocytes using a sandwich ELISA
- as a toll-like receptor 2/6 (TLR2/6) agonist to explore its potential to induce tumoricidal M1 macrophage phenotype
Ações bioquímicas/fisiológicas
Lipoteichoic acid (LTA) is a complex component of cell walls of Gram-positive bacteria that are involved in a wide range of cell processes such as the stimulation of immune responses and cell signaling pathways. LTA differs between species of gram-positive bacteria. Lipoteichoic acid from Streptococcus aureus may be used to compare its structure, immunogenicity and functions versus other bacterial LTAs.
Lipoteichoic acid (LTA) is a complex component of the cell walls of Gram-positive bacteria that are implicated in a wide range of cellular processes such as the stimulation of immune responses and cell signaling pathways. LTA differs between species of Gram-positive bacteria. Lipoteichoic acid from Streptococcus aureus may be used to compare its structure, immunogenicity, and functions versus other bacterial LTAs.
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Nº do produto
Descrição
Preços
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Simin Rezania et al.
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Many types of tumors are organized in a hierarchy of heterogeneous cell populations with different molecular signature. Such heterogeneity may be associated with different responsiveness to microenvironment stimuli. In the present study, the effects of lipopolysaccharide (LPS) and lipoteichoic acid
S Morath et al.
The Journal of experimental medicine, 193(3), 393-397 (2001-02-07)
Lipoteichoic acids (LTAs) have been proposed as putative Gram-positive immunostimulatory counterparts to Gram-negative lipopolysaccharides. However, LTA from Staphylococcus aureus, the clinically most frequent Gram-positive pathogen, was inactive after purification. Here, a novel isolation procedure to prepare pure (>99%) biologically active
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