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SAB4501309

Sigma-Aldrich

Anti-GR antibody produced in rabbit

affinity isolated antibody

Sinônimo(s):

GCR, GRL, GRL1, NR3C1, glucocorticoid receptor

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About This Item

Número MDL:
MFCD01323367
Código UNSPSC:
12352203
NACRES:
NA.41

fonte biológica

rabbit

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

primary antibodies

clone

polyclonal

forma

buffered aqueous solution

peso molecular

antigen 85 kDa

reatividade de espécies

rat, mouse, human

concentração

~1 mg/mL

técnica(s)

ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

nº de adesão NCBI

P04150

nº de adesão UniProt

P04150

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... NR3C1(2908)

Descrição geral

Glucocorticoid receptor (GR) gene/NR3C1 (nuclear receptor subfamily 3 group C member 1) is located on human chromosome 5q31. It belongs to the steroid receptor superfamily that consists of ligand-activated nuclear transcription factors.

Imunogênio

The antiserum was produced against synthesized peptide derived from human GR.

Immunogen Range: 181-230

Aplicação

Anti-GR antibody has been used in western blotting.

Ações bioquímicas/fisiológicas

The glucocorticoid receptor (GR) gene/(NR3C1) is associated with asthma. It is required for glucose homeostasis, hyperinsulinemia and increased fat deposition. It also regulates cell differentiation, nervous and immune system functions.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Renata Cristina Nunes Marchette et al.
Neurobiology of stress, 9, 55-63 (2018-11-20)
Epidemiologic studies have shown that the prevalence of stress-related mood disorders is higher in women, which suggests a different response of neuroendocrine circuits involved in the response to stressful events, as well as a genetic background influence. The aim of
Prolactin and glucocorticoid signaling induces lactation-specific tight junctions concurrent with ?-casein expression in mammary epithelial cells
Kobayashi K, et al.
Biochimica et Biophysica Acta, 1863(8), 2006-2016 (2016)
Yalan Deng et al.
Nature communications, 12(1), 7041-7041 (2021-12-08)
Despite unprecedented responses of some cancers to immune checkpoint blockade (ICB) therapies, the application of checkpoint inhibitors in pancreatic cancer has been unsuccessful. Glucocorticoids and glucocorticoid receptor (GR) signaling are long thought to suppress immunity by acting on immune cells.
Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids
Breslin MB, et al.
Molecular Endocrinology, 15(8), 1381-1395 (2001)
Ken Kobayashi et al.
Biochimica et biophysica acta, 1863(8), 2006-2016 (2016-05-01)
Alveolar mammary epithelial cells (MECs) in mammary glands are highly specialized cells that produce milk for suckling infants. Alveolar MECs also form less permeable tight junctions (TJs) to prevent the leakage of milk components after parturition. In the formation process
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