O1641
Ovalbumin (323-339) (chicken, Japanese quail)
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.26
Produtos recomendados
Ensaio
97-100% (HPLC)
Nível de qualidade
Formulário
lyophilized powder
composição
peptide content, 65-100%
cor
white
solubilidade
water, double-distilled: soluble
temperatura de armazenamento
−20°C
Amino Acid Sequence
H-Ile-Ser-Gln-Ala-Val-His-Ala-Ala-His-Ala-Glu-Ile-Asn-Glu-Ala-Gly-Arg-OH
Descrição geral
Ovalbumin (323-339) is an egg white protein surrounded by B-cell epitopes, which are bound by specific IgE antibodies. In addition to this, it also contains CD4+ T cell epitopes.
The peptide is a major MHC class II-restricted T-cell epitope of Ovalbumin which is used for studies of immunological allergic responses such as asthma, food allergy and more..
Aplicação
Ovalbumin (323-339) (chicken, Japanese quail) has been used to induce allergic asthma in mice.
Ações bioquímicas/fisiológicas
Ovalbumin (OVA) peptide 323-339 mediates 25–35% of T-cell response to intact OVA in isolated BALB/c mouse. OVA 323-339 has been widely used to determine the characteristics of class II major histocompatibility complex (MHC)-peptide binding and T-cell activation.
With the help of two functionally distinct registers ovalbumin (323-339) peptide can bind to histocompatibility complex class II I-A(d) protein.
forma física
Lyophilized from 0.1% aqueous TFA
Outras notas
Lyophilized from 0.1% TFA in H2O
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Ovalbumin(323-339) peptide binds to the major histocompatibility complex class II I-A(d) protein using two functionally distinct registers
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The epitopes for OVA323-339-specific CD4⁺T cells from OVA23-3 food allergy model and DO11.10 tolerant induction model mice were analyzed. We found that OVA23-3 CD4⁺T cells recognized the N-terminal region, showing strong proliferation and the Th2-phenotype, and that DO11.10 CD4⁺T cells
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