M5273

Monensin sodium salt

90-95% (TLC)

• Sinônimo(s): Monensin A sodium salt
• Fórmula empírica (Notação de Hill): C₃₆H₆₁NaO₁₁
• Número CAS: 22373-78-0
• Peso molecular: 692.85
• Beilstein: 4122200
• Número CE: 244-941-7
• Número MDL: MFCD00077826
• Código UNSPSC: 12352200
• ID de substância PubChem: 24896992
• NACRES: NA.77

Propriedades

• Ensaio: 90-95% (TLC)
• espectro de atividade do antibiótico: Gram-negative bacteria; Gram-positive bacteria; fungi; parasites; viruses
• Modo de ação: cell membrane | interferes
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: [H][C@]1([C@@]2(CC)O[C@]([C@@]3(C)OC4(C[C@H](O)[C@@H](C)[C@@]([H])([C@@H](C)[C@@H](OC)[C@@H](C([O-])=O)C)O4)CC3)([H])CC2)[C@@H](C)C[C@]([H])([C@@]5([H])O[C@@](O)(CO)[C@H](C)C[C@@H]5C)O1.[Na+]
• InChI: 1S/C36H62O11.Na/c1-10-34(31-20(3)16-26(43-31)28-19(2)15-21(4)36(41,18-37)46-28)12-11-27(44-34)33(8)13-14-35(47-33)17-25(38)22(5)30(45-35)23(6)29(42-9)24(7)32(39)40;/h19-31,37-38,41H,10-18H2,1-9H3,(H,39,40);/q;+1/p-1/t19-,20-,21+,22+,23-,24-,25-,26+,27+,28-,29+,30-,31+,33-,34-,35?,36-;/m0./s1
• chave InChI: XOIQMTLWECTKJL-BEMBKCOJSA-M

Descrição

Descrição geral

Chemical structure: polyether

Monensin is a polyether ionophoric antibiotic, which is produced by Streptomyces cinnamonensis. It is used to treat bacterial, fungal and parasitic infections. Monensin prevents the growth of colon cancer cells. It facilitates the transport of sodium and potassium ions between intracellular and extracellular spaces. Monensin prevents coccidiosis in poultry production.

Aplicação

Monensin sodium salt has been used:

• for the intracellular staining of cytokines
• to study its effects on the regulation of nuclear factor-κ B (NF-κB ) activation
• as a positive control to study its effects on in vitro rumen fermentation

Ações bioquímicas/fisiológicas

Na⁺ ionophore; blocks glycoprotein secretion; may induce catecholamine secretion from chromaffin cells. Useful in potentiometric and spectroscopic studies of alkali metal ion complexes.

Nota de preparo

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.

Informações de segurança

• Pictogramas: GHS06,GHS08,GHS09
• Palavra indicadora: Danger
• Frases de perigo: H300,H319,H373,H411
• Declarações de precaução: P260 - P264 - P273 - P301 + P310 - P305 + P351 + P338 - P314
• Classificações de perigo: Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - STOT RE 2
• Órgãos-alvo: Heart,muscle
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges