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M2525

Sigma-Aldrich

Mianserin hydrochloride

Sinônimo(s):

1,2,3,4,10,14b-Hexahydro-2-methyl-dibenzo[c,f]pyrazino[1,2-a]azepine hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C18H20N2 · HCl
Número CAS:
21535-47-7
Peso molecular:
300.83
Número CE:
244-426-7
Número MDL:
MFCD00055072
Código UNSPSC:
12352200
ID de substância PubChem:
24278125
NACRES:
NA.77

Nível de qualidade

200

solubilidade

H2O: 3.4 mg/mL
ethanol: 5.6 mg/mL

originador

Organon

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cl.CN1CCN2C(C1)c3ccccc3Cc4ccccc24

InChI

1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H

chave InChI

YNPFMWCWRVTGKJ-UHFFFAOYSA-N

Informações sobre genes

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , HRH1(3269) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)

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Aplicação

Mianserin hydrochloride has been used:
  • as a reversible antagonist for serotonergic -protein coupled receptor (GPCR) - G-protein protein-coupled receptor (S7.1R)
  • as an antidepressant in hippocampal astrocytes to test its effect on brain-derived neurotrophic factor (BDNF) mRNA expression
  • as a 5-hydroxytryptamine (5-HT) receptor antagonist to study its effect on serotonin modulation

Ações bioquímicas/fisiológicas

Antidepressant; antagonist/inverse agonist at 5-HT2 serotonin receptors; also blocks the H1 histamine receptor and the α2 adrenoceptor.
Mianserin is a tetracyclic compound with sedative property. It lacks anticholinergic activity and is not effective on serotoninergic mechanisms. Mianserin is eliminated post biotransformation as hydroxylation, N-oxidation and N-demethylation products.

Características e benefícios

This compound was developed by Organon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Nota de preparo

Solutions may be stored for several days at 4°C.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
029H0631
103H0716
038H47274
022H0444
109F0770

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P A Lavoie et al.
European journal of pharmacology, 369(3), 387-390 (1999-05-04)
In order to test potential links with other stereospecific neurobiological effects of mianserin, the present study explored the stereospecificity for inhibition of depolarization-induced Ca2+ uptake by mianserin. Synaptosomes from rat hippocampus were incubated with 45Ca2+ in either resting or depolarizing
D L Willins et al.
Neuroscience, 91(2), 599-606 (1999-06-12)
In this study, we demonstrate that clozapine and other atypical antipsychotic drugs induce a paradoxical internalization of 5-hydroxytryptamine-2A receptors in vitro and a redistribution of 5-hydroxytryptamine-2A receptors in vivo. We discovered that clozapine, olanzapine, risperidone and the putative atypical antipsychotic
I M Leitch et al.
The Journal of pharmacy and pharmacology, 44(4), 315-320 (1992-04-01)
Some in-vitro pharmacological effects of a novel analogue of mianserin, 2-carboxamidino-1,2,3,4,10,14b-hexahydrodibenzo (c,f) pyrazino (1,2-alpha) azepine hydrochloride (FCC5) have been studied. FCC5 was a non-competitive antagonist of both histamine-induced contractions of the guinea-pig ileum and 5-HT-induced contractions of rat fundal strips
T de Boer
International clinical psychopharmacology, 10 Suppl 4, 19-23 (1995-12-01)
Mirtazapine is a new antidepressant with a unique mode of action: it preferentially blocks the noradrenergic alpha2-auto- and heteroreceptors held responsible for controlling noradrenaline and serotonin release. In addition, mirtazapine has a low affinity for serotonin (5-HT)1A receptors but potently
J A Harvey et al.
Psychopharmacology, 141(2), 162-168 (1999-02-10)
This study examined the role of the serotonin 5-HT2 receptor in motor function by examining the effect of antagonists on the motor performance of a cranial nerve reflex, the nictitating membrane (NM) reflex of the rabbit. The NM reflex was
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