M1523

Muscimol

≥98% (TLC), powder, GABAA receptor agonist.

• Sinônimo(s): 3-Hydroxy-5-aminomethyl-isoxazole, 5-Aminomethyl-3-hydroxy-isoxazole, 5-Aminomethyl-3-isoxazolol, Agarine, Pantherine
• Fórmula empírica (Notação de Hill): C₄H₆N₂O₂
• Número CAS: 2763-96-4
• Peso molecular: 114.10
• Beilstein: 1618960
• Número CE: 220-430-4
• Número MDL: MFCD00057894
• Código UNSPSC: 12352200
• ID de substância PubChem: 24896662
• NACRES: NA.77

Propriedades

• product name: Muscimol, powder
• forma: powder
• Nível de qualidade: 200
• cor: white to off-white
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: NCC1=CC(=O)NO1
• InChI: 1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
• chave InChI: ZJQHPWUVQPJPQT-UHFFFAOYSA-N
• Informações sobre genes: rat ... Gabra2(29706)

Descrição

Descrição geral

Muscimol is a psychoactive isoxazole component, which is found in Amanita muscaria and related mushrooms. It lowers cerebral glucose metabolism and increases the level of 5-hydroxytryptamine in brain. Muscimol has hallucinogenic effects. It is associated with distorted perceptions, nausea and vomiting.

Aplicação

Muscimol has been used:

• to reduce conditioned fear-expression in lateral amygdala (LA)
• to eliminate cortical cell response in ferrets
• to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in zebra finches

Ações bioquímicas/fisiológicas

GABA_A receptor agonist.

Características e benefícios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H300,H336
• Declarações de precaução: P261 - P264 - P271 - P301 + P310 - P304 + P340 + P312 - P403 + P233
• Classificações de perigo: Acute Tox. 2 Oral - STOT SE 3
• Órgãos-alvo: Central nervous system
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges