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M1544

Sigma-Aldrich

Resorufin methyl ether

Sinônimo(s):

7-Methoxy-3H-phenoxazin-3-one, Methoxyresorufin, O7-Methylresorufin

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About This Item

Fórmula empírica (Notação de Hill):
C13H9NO3
Número CAS:
5725-89-3
Peso molecular:
227.22
Beilstein:
209529
Número MDL:
MFCD00037663
Código UNSPSC:
12161501
ID de substância PubChem:
24896665
NACRES:
NA.47

Ensaio

≥98.0% (HPLC)

Nível de qualidade

200

forma

powder

pf

≥220 °C (lit.)

solubilidade

dichloromethane: 0.95-1.05 mg/mL, clear, orange to very deep orange

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

COc1ccc2N=C3C=CC(=O)C=C3Oc2c1

InChI

1S/C13H9NO3/c1-16-9-3-5-11-13(7-9)17-12-6-8(15)2-4-10(12)14-11/h2-7H,1H3

chave InChI

KNYYMGDYROYBRE-UHFFFAOYSA-N

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Aplicação

Resorufin methyl ether have been used as substrate in the incubation mixture, during the determination of cytochrome P4501A activities such as ethoxyresorufin O-deethylase (EROD) and methoxyresorufin O-demethylase(MROD) in liver microsomes, using high performance liquid chromatography(HPLC).

Ações bioquímicas/fisiológicas

Fluorimetric substrate for cytochrome P450 linked enzymes.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Dissecting the insecticide-resistance- associated cytochrome P450 gene Cyp6g1.
McCart C and ffrench-Constant R H
Pest Management Science, 64(6), 639-645 (2008)
Determination of cytochrome P450 1A activities in mammalian liver microsomes by high-performance liquid chromatography with fluorescence detection
Hanioka N, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 744(2), 399-406 (2000)
Nicholas E Hadjokas et al.
British journal of pharmacology, 136(3), 347-352 (2002-05-25)
1. Cytochrome P4501A2 (CYP1A2) activates a large number of procarcinogens to carcinogens. Phytochemicals such as flavones can inhibit CYP1A2 activity competitively, and hydroxylated derivatives of flavone (galangin) may be potent, selective inhibitors of CYP1A2 activity relative to CYP1A1 activity. Molecular
M Teresa Donato et al.
Drug metabolism and disposition: the biological fate of chemicals, 34(9), 1556-1562 (2006-06-10)
Liver grafts discarded for transplantation because of macrosteatosis can constitute a valuable source of human hepatocytes for in vitro metabolic and pharmacotoxicological studies or for therapeutic applications. A condition for using hepatocyte suspensions for these purposes is the preservation of
Yune-Fang Ueng et al.
The Journal of pharmacy and pharmacology, 57(2), 227-232 (2005-02-22)
Rutaecarpine is a main active alkaloid present in the medicinal herb, Evodia rutaecarpa. The cytochrome P450 (CYP) 1A2 substrate, theophylline, is an important therapeutic agent for the treatment of asthma, but has a narrow therapeutic index. To evaluate the pharmacokinetic
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Phase I Drug Metabolism

Phase I biotransformation reactions introduce or expose functional groups on the drug with the goal of increasing the polarity of the compound. Although Phase I drug metabolism occurs in most tissues, the primary and first pass site of metabolism occurs during hepatic circulation.

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