M1275

Naproxen sodium

98.0-102.0%

• Sinônimo(s): (S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid sodium salt
• Fórmula empírica (Notação de Hill): C₁₄H₁₃NaO₃
• Número CAS: 26159-34-2
• Peso molecular: 252.24
• Número CE: 247-486-2
• Número MDL: MFCD00058507
• Código UNSPSC: 12352200
• ID de substância PubChem: 57654352
• NACRES: NA.77

Propriedades

• fonte biológica: synthetic (organic)
• Ensaio: 98.0-102.0%
• Formulário: powder
• solubilidade: water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow
• originador: Bayer
• cadeia de caracteres SMILES: [Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O
• InChI: 1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1
• chave InChI: CDBRNDSHEYLDJV-FVGYRXGTSA-M
• Informações sobre genes: human ... PTGS1(5742) , PTGS2(5743)

Descrição

Descrição geral

Naproxen belongs to phenylacetic acid class of Non-steroidal anti-inflammatory drugs (NSAIDs).

Aplicação

Naproxen sodium has been used to evaluate the thermodynamics of biomolecular interaction with bovine and human serum albumin. It has also been used to evaluate its efficiency in reducing the response of spinal dorsal horn neurons to noxious knee joint rotation.

Ações bioquímicas/fisiológicas

Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.

Naproxen binds preferably to serum albumin. The S-enantiomer of naproxen is 28-fold more potential as an anti-inflammatory drug compared to the R-isomer. The R-isomer is found to be a liver toxin and causes gastrointestinal disorders.

Características e benefícios

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS08,GHS07
• Palavra indicadora: Danger
• Frases de perigo: H302,H360
• Declarações de precaução: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Classificações de perigo: Acute Tox. 4 Oral - Repr. 1A
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves