L9783

Leupeptin hydrochloride

powder, ≥90% (HPLC)

• Sinônimo(s): Acetyl-Leu-Leu-Arg-al hydrochloride
• Fórmula empírica (Notação de Hill): C₂₀H₃₈N₆O₄ · HCl
• Número CAS: 24125-16-4
• Peso molecular: 463.01
• Número MDL: MFCD00133457
• Código UNSPSC: 12352202
• ID de substância PubChem: 24896529
• NACRES: NA.77

Propriedades

• Nome do produto: Leupeptin hydrochloride, microbial, ≥90% (HPLC)
• fonte biológica: microbial
• Nível de qualidade: 200
• Ensaio: ≥90% (HPLC)
• Formulário: powder
• solubilidade: water: 50 mg/mL, clear, colorless
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: Cl.CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C=O
• InChI: 1S/C20H38N6O4.ClH/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);1H
• chave InChI: OQQYPQNFLLAILR-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM.

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

Nota de análise

Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)