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Merck
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Key Documents

L6520

Sigma-Aldrich

Prolactin from sheep pituitary

20-50 IU/mg

Sinônimo(s):

LTH, Lactogenic hormone from ovine pituitary glands, Luteotropic Hormone, PRL

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About This Item

Número CAS:
9002-62-4
Número MDL:
MFCD00131553
Código UNSPSC:
51111800
NACRES:
NA.32

forma

powder

atividade específica

20-50 IU/mg

solubilidade

water: 7 mg/mL, clear to slightly hazy, colorless to faintly yellow

nº de adesão UniProt

P01240

Condições de expedição

ambient

temperatura de armazenamento

2-8°C

Informações sobre genes

sheep ... PRL(443317)

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Ações bioquímicas/fisiológicas

Prolactin is a neuroendocrine hormone. The prolactin receptor is a transmembrane glycoprotein that belongs to the cytokine hematopoietic receptor family. A large number of cells and organs express the receptor, including B cells, T cells, macrophages, monocytes and neutrophils. Prolactin signal transduction involves the JAK/STAT families and the src kinase family. Induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.

Pictogramas

Health hazard
GHS08

Palavra indicadora

Danger

Frases de perigo

H360

Declarações de precaução

P201 - P308 + P313

Classificações de perigo

Repr. 1B

Código de classe de armazenamento

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Lipopolissacarídeos γ-irradiated, BioXtra, suitable for cell culture

Sigma-Aldrich

L6529

Lipopolissacarídeos

Timestrip Plus™ 8 °C

Supelco

08168

Timestrip Plus™ 8 °C

Sharon R Ladyman et al.
eLife, 10 (2021-09-17)
As part of the maternal adaptations to pregnancy, mice show a rapid, profound reduction in voluntary running wheel activity (RWA) as soon as pregnancy is achieved. Here, we evaluate the hypothesis that prolactin, one of the first hormones to change
Jakub Sumbal et al.
Frontiers in cell and developmental biology, 8, 68-68 (2020-04-09)
Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in mammary epithelium, as well as surrounding stroma.
Khalid Bajou et al.
Nature medicine, 20(7), 741-747 (2014-06-16)
The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown. Here, we found that 16K PRL binds the fibrinolytic inhibitor plasminogen activator inhibitor-1 (PAI-1), which is known to contextually promote tumor
Etienne Delgrange et al.
European journal of endocrinology, 170(1), 31-38 (2013-10-04)
To characterise distinctive clinical features of giant prolactinomas in women. A multicentre, retrospective case series and literature review. We collected data from 15 female patients with a pituitary tumour larger than 4 cm and prolactin levels above 1000 μg/l and
Akie Nakamura et al.
The Journal of clinical endocrinology and metabolism, 98(10), E1682-E1691 (2013-08-24)
Congenital central hypothyroidism (C-CH) is a rare disease. We investigated the molecular basis of unexplained C-CH in 4 Japanese boys. C-CH was diagnosed by low free T4 and/or T3 and low basal TSH concentrations. We used whole-exome sequencing of one
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