L6010
α-Lactalbumin from bovine milk
Type III, calcium depleted, ≥85% (PAGE), lyophilized powder
Sinônimo(s):
Bos d 4, Lactose synthase B protein, alpha-lactalbumin
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About This Item
Produtos recomendados
fonte biológica
bovine milk
Nível de qualidade
tipo
Type III
Ensaio
≥85% (PAGE)
Formulário
lyophilized powder
qualidade
calcium depleted
peso molecular
14,178 Da by calculation
concentração
≥85 % protein
técnica(s)
indirect ELISA: suitable
Impurezas
cation traces, tested
solubilidade
H2O: soluble 10 mg/mL, clear to slightly hazy, colorless to faintly yellow
traços de cátion
Ca: ≤0.3 mol/mol
nº de adesão UniProt
temperatura de armazenamento
−20°C
Informações sobre genes
cow ... LALBA(281894)
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Descrição geral
may contain traces of (NH4)2SO4 and sodium phosphateL6010
Aplicação
α-Lactalbumin from bovine milk has been used:
- in indirect enzyme-linked immunosorbent assay (ELISA) and competitive ELISA methods
- in binding of Hsp90 and HSJ1b analysis
- to inhibit the lysozyme CAP-RAST assay
Ações bioquímicas/fisiológicas
α-Lactalbumin is the cheif protein in human milk. It consists of a single polypeptide chain with 8 cysteines which form disulfide bridges. α-Lactalbumin binds several metal ions, including calcium, which is thought to play a role in the regeneration of native α-lactalbumin from the reduced, denatured form. α-Lactalbumin also has a distinct zinc binding site that is thought to play a role in the binding of the lactose synthase complex.The mature protein consists of 123 amino acid residues (14 kD), and it has a three-dimensional structure with 1.7 Angstrom resolution, demonstrating four α-helices and a triple stranded antiparallel β-sheet.
Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase.
Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase. Site-directed mutagenesis of Asp87 or Asp88 to Ala completely abolishes the strong calcium binding affinity and reduces the stimulation of lactose synthase to <3.5% of the maximal rate.
Qualidade
May contain traces of (NH4)2SO4 and sodium phosphate.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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