L3382
Lectin from Helix pomatia
lyophilized powder, salt, free
Sinônimo(s):
Helix pomatia agglutinin, HPA
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About This Item
Código UNSPSC:
12352202
NACRES:
NA.32
Produtos recomendados
Formulário
lyophilized powder
Nível de qualidade
potência
<4 μg per mL agglutination activity
Impurezas
salt, free
temperatura de armazenamento
−20°C
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Descrição geral
Lectin from Helix pomatia is a hexameric glycoprotein with a molecular mass of 79 kDa. It issecreted by the albumen gland of the roman snail. Helix pomatia agglutinin (HPA) is specific for N-acetylgalactosamine (GalNAc).
Aplicação
Lectin from Helix pomatia has been used to conjugate with biotin and acridinium and used in lectin-agglutination tests.
Ações bioquímicas/fisiológicas
HPA has anti-A human blood group specificity and has an affinity for terminal N-acetyl-α-D-galactosaminyl residues. Conjugates are prepared from affinity purified lectin.
Lectin from Helix pomatia protects fertilized eggs by coating them with perivitelline fluid. They exhibit antibacterial activities and immunity in snail. Helix pomatia agglutinin (HPA) possess the potential to agglutinate pathogens. HPA has also emerged as a marker of altered Oglycosylation in cancer.
Nota de preparo
Affinity purified by a modification of the method of Hammarstrom and Kabat.
Nota de análise
Where reported, agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, of a 1 mg/ml solution. This activity is the lowest concentration to agglutinate a 2% suspension of human blood group A erythrocytes after 1 hour incubation at 25 °C.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Hammarstrom, S., and Kabat, E.A.
Biochemistry, 95, 311-311 (1978)
Biochemical and structural analysis of helix pomatia agglutinin a hexameric lectin with a novel fold
Sanchez JF, et al.
The Journal of biological chemistry, 281(29), 20171-20180 (2006)
Binding of aberrant glycoproteins recognizable by Helix pomatia agglutinin in adrenal cancers
Parameswaran R, et al.
BJS open, 2(5), 353-359 (2018)
Katie Barr et al.
Transfusion, 55(1), 129-136 (2014-07-22)
The FORS blood group system (originally recognized as the Apae phenotype) was discovered by sporadic activity against polyclonal anti-A reagents and activity against the lectin Helix pomatia. The extent of monoclonal anti-A reagent activity against the FORS1 antigen is serologically
Characterization of bovine and human group B streptococci isolated in Turkey
Ekin IH and Gurturk K
Journal of Medical Microbiology, 55(5), 517-521 (2006)
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