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Documentos Principais

I6635

Sigma-Aldrich

Monoclonal Anti-Secretory Component (IgA) antibody produced in mouse

clone GA-1, ascites fluid

Sinônimo(s):

IgA Antibody, Secretory Component Antibody

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.46

fonte biológica

mouse

conjugado

unconjugated

forma do anticorpo

ascites fluid

tipo de produto de anticorpo

primary antibodies

clone

GA-1, monoclonal

contém

15 mM sodium azide

reatividade de espécies

human

técnica(s)

indirect ELISA: 1:10,000

Isotipo

IgG1

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Descrição geral

The secretory component is a single chain glycoprotein that may occur freely or as component of the secretory immunoglobulin A (SIgA). IgA regulates the physiological balance between commensal intestinal bacteria and the defenses of the host immune system. It is the highest generated antibody isotype. IgAs are mainly secreted in the intestinal mucosa and prevent the commensal microorganisms from invading the intestines
Monoclonal Anti-Secretory Component (IgA) antibody is specific for secretory human IgA and the free secretory component. The antibody does not bind to human IgG, IgM and IgE.

Imunogênio

Secretory component purified from human colostrum

Aplicação

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Chromatin immunoprecipitation (1 paper)
Monoclonal Anti-Secretory Component (IgA) antibody has been used in immunohistochemistry analysis and serological assays.
Monoclonal Anti-Secretory Component (IgA) antibody is suitable for use in EIA and western blot. The product may also be used for indirect ELISA (1:10,000).

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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C G Engeland et al.
Brain, behavior, and immunity, 52, 11-17 (2015-09-01)
Stress-induced impairments of mucosal immunity may increase susceptibility to infectious diseases. The present study investigated the association of perceived stress, depressive symptoms, and loneliness with salivary levels of secretory immunoglobulin A (S-IgA), the subclasses S-IgA1, S-IgA2, and their transporter molecule
Salivary antibody response to vaccination with meningococcal A/C polysaccharide vaccine in previously vaccinated and unvaccinated Gambian children
Nurkka A, et al.
Vaccine, 19(4-5), 547-556 (2000)
Influence of reactive oxygen species on secretory component in the intestinal epithelium during hyperoxia
Zhao M, et al.
Experimental and Therapeutic Medicine, 14(5), 4033-4040 (2017)
B Simell et al.
The Journal of infectious diseases, 183(6), 887-896 (2001-03-10)
Local antibodies probably contribute to defense against Streptococcus pneumoniae. This study examined whether pneumococcal carriage and acute otitis media (AOM) induce mucosal antibodies to potential vaccine candidates pneumococcal surface adhesin A (PsaA), pneumolysin (Ply), and pneumococcal surface protein A (PspA).
Muna Sapkota et al.
Alcoholism, clinical and experimental research, 41(12), 2093-2099 (2017-09-25)
Malondialdehyde (MDA) and acetaldehyde (AA) exist following ethanol metabolism and tobacco pyrolysis. As such, lungs of individuals with alcohol use disorders (AUDs) are a target for the effects of combined alcohol and cigarette smoke metabolites. MDA and AA form a

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