I4036
IgA from human serum
reagent grade, ≥95% (HPLC), buffered aqueous solution
Sinônimo(s):
Human IgA
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About This Item
Código UNSPSC:
12352203
NACRES:
NA.41
Produtos recomendados
conjugado
unconjugated
Nível de qualidade
grau
reagent grade
Ensaio
≥95% (HPLC)
forma
buffered aqueous solution
temperatura de armazenamento
−20°C
Descrição geral
IgA is one of the most abundant antibody isotypes produced in the body. It is mainly secreted by plasma cells located in the lamina propria. There are two subtypes of IgA, IgA1 and IgA2 present primarily in the airways and colon, respectively.
Aplicação
IgA from human serum has been used in enzyme-linked immunosorbent assay (ELISA) for anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-spike-receptor binding domain (RBD) antibody detection in blood samples.
Purified human IgA may be used to study its physiological and biological effects on processes such as inflammation, pathogen elimination, regulation of antibody-dependent-cell-mediated cytotoxicity (ADCC), modulation of phagocytosis, degranulation of eosinophils and basophils and modulation of respiratory burst activity.
Ações bioquímicas/fisiológicas
IgA aids in inducing a defense mechanism against various viral pathogens such as rotavirus, poliovirus, influenza virus, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It regulates excessive immune responses in inflammatory diseases. IgA also has the potential to trigger neutrophil recruitment for cell killing.
forma física
Solution in 0.01 M Phosphate Buffer saline, pH 7.4, containing 15 mM sodium azide as a preservative.
Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Rafael D Melani et al.
medRxiv : the preprint server for health sciences (2021-07-17)
Methods of antibody detection are used to assess exposure or immunity to a pathogen. Here, we present Ig-MS , a novel serological readout that captures the immunoglobulin (Ig) repertoire at molecular resolution, including entire variable regions in Ig light and
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Journal of proteome research, 21(1), 274-288 (2021-12-09)
Methods of antibody detection are used to assess exposure or immunity to a pathogen. Here, we present Ig-MS, a novel serological readout that captures the immunoglobulin (Ig) repertoire at molecular resolution, including entire variable regions in Ig light and heavy
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Accurate diagnosis of acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical for appropriate management of patients with this disease. We examined the possible complementary role of laboratory-developed class-specific clinical serology in assessing SARS-CoV-2 infection in hospitalized patients.
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The Journal of clinical investigation, 130(2), 927-941 (2019-11-07)
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Journal of immunology (Baltimore, Md. : 1950), 200(12), 3913-3925 (2018-05-02)
Prevalence of circulating immunocomplexes (ICs) strongly correlates with rheumatoid arthritis (RA) in humans. Deposits of IgG-ICs are abundant in affected joints of patients, yet molecular mechanisms for the pathogenic roles of such ICs are not fully understood. In this study
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