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Documentos Principais

I1646

Sigma-Aldrich

IL-3 human

≥97% (HPLC and SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinônimo(s):

Interleukin-3 human, hIL-3, IL-3

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About This Item

Número MDL:
MFCD00147276
Código UNSPSC:
12352202
NACRES:
NA.77

Nome do produto

Interleukin-3 human, IL-3, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

fonte biológica

human

Nível de qualidade

200

recombinante

expressed in E. coli

Ensaio

≥97% (HPLC and SDS-PAGE)

Formulário

lyophilized powder

potência

≤1.0 ng/mL ED50/EC50

qualidade

endotoxin tested

peso molecular

15 kDa

embalagem

pkg of 10 and 50 μg

condição de armazenamento

avoid repeated freeze/thaw cycles

técnica(s)

cell culture | mammalian: suitable

Impurezas

≤0.1 EU/μg

nº de adesão UniProt

P08700

temperatura de armazenamento

−20°C

Informações sobre genes

human ... IL3(3562)

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Categorias relacionadas

Ações bioquímicas/fisiológicas

Interleukin-3 (IL-3) is a multifunctional protein, originally called colony forming unit-stimulating activity (CFU-SA), and is produced by activated T lymphocytes. IL-3 supports the formation of multilineage colonies in the early development of multipotent hematopoietic progenitor cells. IL-3 has been shown to induce colony formation of macrophages, neutrophils, mast cells, and megakaryocytes from agar-suspended bone marrow cells. IL-3 also interacts with IL-2 to stimulate growth of T lymphocytes and to induce IgG secretion from activated B cells. Other synonyms for IL-3 include pan-specific hemopoietin, multicolony stimulating factor, mast cell growth factor, burst promoting activity, histamine-producing cell stimulating factor, P cell stimulating factor, and WEHI-3 factor.
Interleukin-3 is a multifunctional protein produced by activated T lymphocytes. IL-3 supports the formation of multilineage colonies in the early development of multipotent hematopoietic progenitor cells. IL-3 also interacts with IL-2 to stimulate growth of T lymphocytes and induce IgG secretion from activated B cells.

forma física

Lyophilized with no additives. Sterile filtered through a 0.2 μm filter.

Nota de análise

The biological activity is measured by the dose-dependent stimulation of the proliferation of human TF-1 cells.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
SLCL6950
SLCK9617
SLCJ0407
SLCH0548
SLCD8353

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Bingrui Wang et al.
Cell discovery, 8(1), 41-41 (2022-05-10)
Ribosomal protein dysfunction causes diverse human diseases, including Diamond-Blackfan anemia (DBA). Despite the universal need for ribosomes in all cell types, the mechanisms underlying ribosomopathies, which are characterized by tissue-specific defects, are still poorly understood. In the present study, we
S Yousefi et al.
Allergy, 70(9), 1184-1188 (2015-06-05)
Basophils are primarily associated with immunomodulatory functions in allergic diseases and parasitic infections. Recently, it has been demonstrated that both activated human and mouse basophils can form extracellular DNA traps (BETs) containing mitochondrial DNA and granule proteins. In this report
Hai Zhou et al.
Thrombosis and haemostasis, 113(5), 1021-1034 (2015-01-09)
Impaired megakaryocyte maturation and insufficient platelet production have been shown to participate in the pathogenesis of immune thrombocytopenia (ITP). Our previous study demonstrated that low expression of tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) in megakaryocytes contributed to impaired platelet production
Jinhua Liu et al.
Nature communications, 9(1), 4386-4386 (2018-10-24)
In addition to serving as a prosthetic group for enzymes and a hemoglobin structural component, heme is a crucial homeostatic regulator of erythroid cell development and function. While lncRNAs modulate diverse physiological and pathological cellular processes, their involvement in heme-dependent
Kerstin Kapp et al.
Molecular therapy. Nucleic acids, 3, e170-e170 (2014-06-25)
Toll-like receptors are sensing modulators of the innate immune system. One member of this protein family, Toll-like receptor (TLR)-9, is increasingly being investigated as therapeutic target for infectious diseases and cancer. Double-Stem Loop ImmunoModulator (dSLIM) is a new TLR-9 agonist
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