I1395

Interleukin-6 human

IL-6, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• Sinônimo(s): hIL-6, IL-6
• Número MDL: MFCD00131403
• Código UNSPSC: 12352202
• NACRES: NA.77

Propriedades

• fonte biológica: human
• Nível de qualidade: 300
• recombinante: expressed in E. coli
• Ensaio: ≥97% (SDS-PAGE)
• forma: lyophilized powder
• potência: 0.2-2.0 ng/mL ED₅₀/EC₅₀
• qualidade: endotoxin tested
• peso molecular: 26 kDa
• embalagem: pkg of 10 and 50 μg
• condição de armazenamento: avoid repeated freeze/thaw cycles
• técnica(s): cell culture | mammalian: suitable
• Impurezas: ≤1.000 EU/μg
• cor: white
• nº de adesão UniProt: P05231
• temperatura de armazenamento: −20°C
• Informações sobre genes: human ... IL6(3569)

Descrição

Ações bioquímicas/fisiológicas

Interleukin-6 (IL-6) is a multifunctional protein originally discovered in the media of cells stimulated with double stranded RNA. IL-6 appears to be directly involved in the responses that occur after infection and injury and may prove to be as important as IL-1 and TNF-α in regulating the acute phase response. IL-6 is reported to be produced by fibroblasts, activated T cells, activated monocytes or macrophages, and endothelial cells. It acts upon a variety of cells, including fibroblasts, myeloid progenitor cells, T cells, B cells and hepatocytes. IL-6 induces multiple effects, as indicated by its numerous synonyms: plasmacytoma growth factor (PCT-GF), interferon-β-2 (IFN-β₂), monocyte derived human B cell growth factor, B cell stimulating factor (BSF-2), hepatocyte stimulating factor (HSF), Interleukin Hybridoma/Plasmacytoma-1 (IL-HP1). In addition, IL-6 appears to interact with IL-2 in the proliferation of T lymphocytes. IL-6 also potentiates the proliferative effect of IL-3 on multipotential hematopoietic progenitors.

forma física

Lyophilized from a 0.2 μm filtered solution of phosphate buffer saline (PBS), pH 7.4, containing 500 μg bovine serum albumin.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H315,H319,H335
• Declarações de precaução: P261 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)