H140

(R)-(+)-8-Hydroxy-DPAT hydrobromide

≥98% (HPLC), solid

• Sinônimo(s): (R)-(+)-2-Dipropylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide, (R)-(+)-8-Hydroxy-2-(dipropylamino)tetralin hydrobromide
• Fórmula empírica (Notação de Hill): C₁₆H₂₅NO · HBr
• Número CAS: 78095-19-9
• Peso molecular: 328.29
• Número MDL: MFCD00153810
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278480
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• Formulário: solid
• atividade óptica: [α]25/D +68.2°, c = 1 in methanol(lit.)
• condição de armazenamento: desiccated; protect from light
• cor: white to off-white
• solubilidade: H₂O: >10 mg/mL at ±60 °C (with sonication)
• cadeia de caracteres SMILES: Br.CCCN(CCC)[C@@H]1CCc2cccc(O)c2C1
• InChI: 1S/C16H25NO.BrH/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14;/h5-7,14,18H,3-4,8-12H2,1-2H3;1H/t14-;/m1./s1
• chave InChI: BATPBOZTBNNDLN-PFEQFJNWSA-N
• Informações sobre genes: human ... HTR1A(3350)

Descrição

Aplicação

(R)-(+)-8-Hydroxy-DPAT hydrobromide has been used as a 5-HT1A agonist:

• in mice to test the activity of the serotonin receptor
• to test its effect on zebrafish melanocyte migration and survival
• to stimulate hippocampal neurons

Ações bioquímicas/fisiológicas

(R)-(+)-8-Hydroxy-DPAT administration reduces aggressive behavior. It decreases food intake by modifying the sensitivity of 5-HT1A receptor during food deprivation.

(R)-(+)-8-Hydroxy-DPAT is a full 5-HT_1A serotonin receptor agonist; active enantiomer of (±)-8-hydroxy-DPAT.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)