H139

HA-1077 dihydrochloride

solid, ≥98% (HPLC)

• Sinônimo(s): 1-(5-Isoquinolinylsulfonyl)homopiperazine dihydrochloride, Fasudil dihydrochloride
• Fórmula empírica (Notação de Hill): C₁₄H₁₇N₃O₂S · 2HCl
• Número CAS: 203911-27-7
• Peso molecular: 364.29
• Número MDL: MFCD00153805
• Código UNSPSC: 12352200
• ID de substância PubChem: 24895456
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: solid
• condição de armazenamento: desiccated
• cor: white to off-white
• solubilidade: H₂O: >10 mg/mL
• cadeia de caracteres SMILES: Cl[H].Cl[H].O=S(=O)(N1CCCNCC1)c2cccc3cnccc23
• InChI: 1S/C14H17N3O2S.2ClH/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14;;/h1,3-5,7,11,15H,2,6,8-10H2;2*1H
• chave InChI: NOXXIYDYFSNHDF-UHFFFAOYSA-N

Descrição

Aplicação

HA-1077 dihydrochloride has been used:

• to relax cantilevers
• in the functional assessment of isolated coronary arteries
• to investigate the effect of azaindole-1, fasudil on acute hypoxic pulmonary vasoconstriction (HPV)

Ações bioquímicas/fisiológicas

HA-1077/fasudil, is a Rho kinase inhibitor. This ROCK inhibitor has the ability to increase cognitive deficits in animals, that have Alzheimer′s disease (AD). In humans, fasudil possesses high therapeutic effects against cerebral vasospasm after subarachnoid hemorrhage (SAH). HA-1077 also acts as an inhibitor of protein kinases, like myosin light chain kinase and Rho associated kinase. Hence, it can block myosin phosphorylation.

Novel vasodilator agent which inhibits vascular smooth muscle contraction by acting as an intracellular Ca²⁺ antagonist.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)