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Key Documents

G7516

Sigma-Aldrich

γγ-Globulinas

≥97% (agarose gel electrophoresis)

Sinônimo(s):

γ-globulina bovina

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About This Item

Número CAS:
Número CE:
Número MDL:
Código UNSPSC:
12352202
NACRES:
NA.61

fonte biológica

bovine blood

Ensaio

≥97% (agarose gel electrophoresis)

forma

powder

composição

NaCl, ≤5%

solubilidade

0.9% NaCl: soluble 50 mg/mL

temperatura de armazenamento

−20°C

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Descrição geral

A gamaglobulina bovina (BGG) é um componente importante do sistema imunológico de vacas e outros bovinos. A BGG é encontrada no sangue de bovinos e é usada principalmente na produção de produtos médicos, como vacinas, soros e reagentes de diagnóstico. A BGG também pode ser usada para tratar certas condições médicas, como a hepatite B, bem como para aumentar a imunidade em humanos e outros animais.
The γG globulins of bovine serum are categorized by anion exchange chromatography, immunoelectrophoresis, zone electrophoresis, ultracentrifugation, and analysis of the products of papain digestion. They have properties similar to analogous components of human serum. This was determined by the methods such as: gel filtration, immunoelectrophoresis, anion exchange chromatography, ultracentrifugation, and reduction with mercaptoethanol. Fast and slow γG globulins were classified on the basis of differences in electrophoretic migration rates, chromatographic elution positions, and biological activities (complement fixation). Bovine γA was conditionally found in immunoelectrophoretic analyses of serum and chromatographic fractions.

Aplicação

γ-globulin has been used as an immunological challenge in studies of mechanisms of immunotolerance.
Bovine γ-globulins were used to study the constituents and pH changes in protein rich hyaluronan solution affecting the bio-tribological properties of artificial articular joints. It is also used to determine immunoglobulin G in bovine colostrum and milk by direct biosensor SPR-immunoassay.
Bovine γ-globulin was used in rapid screening for monensin residues in poultry plasma by a dry reagent dissociation enhanced lanthanide fluoroimmunoassay. It was also tested for the effects of solution properties on solute and permeate flux in bovine serum albumin-IgG ultrafiltration.
A γ-globulina bovina foi usada como desafio imunológico em estudos sobre mecanismos de imunotolerância.

Nota de preparo

Prepared from plasma

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)


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S R Crooks et al.
The Analyst, 123(12), 2493-2496 (1999-08-06)
Monensin, a carboxylic acid ionophore, is commonly fed to poultry to control coccidiosis. A method for rapid analysis of unextracted poultry plasma samples has been developed based on a novel immunoassay format: one-step all-in-one dry reagent time resolved fluorimetry. All
Liyu He et al.
American journal of nephrology, 43(3), 179-194 (2016-04-14)
Immunoglobulin (Ig) A nephropathy (IgAN) is the xFB01;nding of immune deposits predominantly containing polymeric IgA in the glomerular mesangium on renal biopsy. Increasing evidence suggested that retinoic acid (RA) signaling selectively induces IgA isotype switching and basic leucine zipper transcription
R G Nel et al.
Biotechnology progress, 10(5), 539-542 (1994-09-01)
It has been observed that bovine serum albumin (BSA, 69,000 Da) exhibits high rejection in a pH 7.4, 0.15 M NaCl solution containing low concentrations of immuno-gamma-globulins (IgG, 155,000 Da). Although it is apparent that this phenomenon is likely due
Determination of immunoglobulin G in bovine colostrum and milk by direct biosensor SPR-immunoassay.
Indyk HE, Filonzi EL.
Journal of AOAC (Association of Official Analytical Chemists) International, 2, 386-393 (2003)
Physical heterogeneity of bovine gamma-globulins: characterization of gamma-M and gamma-G globulins.
F A Murphy et al.
Archives of biochemistry and biophysics, 112(1), 126-136 (1965-10-01)

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