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T1001

Sigma-Aldrich

Thyroglobulin from bovine thyroid

powder, ≥90% (agarose gel electrophoresis)

Sinônimo(s):

Globulins thyro, Thyractin

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About This Item

Número CAS:
9010-34-8
Número CE:
232-721-3
Número MDL:
MFCD00132429
Código UNSPSC:
12352202
NACRES:
NA.61

fonte biológica

bovine thyroid

Nível de qualidade

200

Ensaio

≥90% (agarose gel electrophoresis)

forma

powder

peso molecular

~670 kDa

composição

Iodine, ≥0.20%

análise de nitrogênio

13.0-16.0% total

cinzas

≤4%

solubilidade

H2O: 20 mg/mL

nº de adesão UniProt

P01267

temperatura de armazenamento

−20°C

Informações sobre genes

cow ... TG(280706)

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Aplicação

Bovine thyroglobulin was shown to stimulate proliferation in rat thyroid follicular cells as well as in primary porcine thyroid epithelial cells. This effect was mediated through PI3K signaling.
Often used as a carrier protein for the production of antibodies. Its advantage is the large number of tyrosine residues that can be used for conjugation using the diazo reaction.

Ações bioquímicas/fisiológicas

Bovine thyroglobulin is a large, tetrameric glycoprotein produced in the thyroid gland as a precursor to thyroid hormones. Its large size and absence from plasma under normal conditions makes it very immunogenic and reduces the chance that antibodies to this carrier protein will cross-react with plasma proteins in immunoassays. Haptens may be conjugated to thyroglobulin via accessible secondary amines.
Iodine-containing protein that is stored in the thyroid gland. Converted into circulating thyroxines when the thyroid is stimulated by thyroid-stimulating hormone (TSH) from the pituitary. Because its expression is unique to the thyroid, it is a sensitive indicator of recurrence or metastasis of thyroid cancer that has been treated by thyroid ablation.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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