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G5168

Sigma-Aldrich

(Z)-Guggulsterone

≥89% (HPLC), powder

Sinônimo(s):

(17Z)-Pregna-4,17(20)-diene-3,16-dione, 4,17(20)-trans-Pregnadiene-3,16-dione

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About This Item

Fórmula empírica (Notação de Hill):
C21H28O2
Número CAS:
39025-23-5
Peso molecular:
312.45
Número MDL:
MFCD01310757
Código UNSPSC:
12352200
ID de substância PubChem:
24278392
NACRES:
NA.77

Nível de qualidade

200

Ensaio

≥89% (HPLC)

forma

powder

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

Impurezas

≤5.4% E-form

cor

light yellow

solubilidade

DMSO: 5 mg/mL

aplicação(ões)

forensics and toxicology
veterinary

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[H][C@@]12CCC3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@]4(C)\C(=C\C)C(=O)C[C@@]24[H]

InChI

1S/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1

chave InChI

WDXRGPWQVHZTQJ-OSJVMJFVSA-N

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Categorias relacionadas

Ações bioquímicas/fisiológicas

(Z)-Guggulsterone is a natural product that lowers cholesterol due to its function as an antagonist ligand for the bile acid receptor. (Z)-Guggulsterone is a nuclear hormone receptor that regulates the transcription of several genes involved in cholesterol metabolism and plays a role in cholesterol level regulation. (Z)-Guggulsterone is also a selective farnesoid X receptor (FXR) modulator.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H335

Classificações de perigo

STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Rodolfo Gonzalez et al.
Scientific reports, 3, 1463-1463 (2013-03-16)
New small molecules that regulate the step-wise differentiation of human pluripotent stem cells into dopaminergic neurons have been identified. The steroid, guggulsterone, was found to be the most effective inducer of neural stem cells into dopaminergic neurons. These neurons are
Dong-Won Ahn et al.
Pancreas, 41(7), 1048-1057 (2012-04-20)
Guggulsterone is a dietary plant sterone possessing therapeutic potential against cancers. However, the antitumor effect of this natural compound on pancreatic cancer has not been determined yet. This study was designed to investigate the therapeutic efficacy of guggulsterone in pancreatic
Inas Almazari et al.
Topics in current chemistry, 329, 35-60 (2012-08-02)
Guggulsterone (GS) is a phytosterol derived from the gum resin of guggul plants that have been used traditionally to treat various disorders such as burns, wounds, gastric ulcer, cough, gum diseases, urinary complaints, diarrhea, stomach cramps, fascioliasis, and intestinal worms.
Caroline Scholtes et al.
Therapie, 67(5), 423-427 (2012-12-18)
To test the modulation of farnesoid X receptor activity on the replication of hepatitis C virus in chronically infected patients. This is a proof-of-concept trial that was approved by the ex-French Agency for the Safety of Health Products (ex-Afssaps [currently
Y T Kamal et al.
Biomedical chromatography : BMC, 26(10), 1183-1190 (2012-01-04)
An attempt has been made to develop and validate a simultaneous HPLC method for novel approach of drug release via oil-in-water (o/w) nanoemulsion formulation and Habb-e-Khardal Unani tablet containing piperine and guggul sterones E and Z as main ingredients. Nanoemulsion
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