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G1895

Sigma-Aldrich

Gly-Pro-Arg-Pro

≥95% (HPLC)

Sinônimo(s):

GPRP, Glycyl-Prolyl-Arginyl-Proline amide

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About This Item

Fórmula empírica (Notação de Hill):
C18H31N7O5
Número CAS:
67869-62-9
Peso molecular:
425.48
Número MDL:
MFCD00133378
Código UNSPSC:
12352209
ID de substância PubChem:
24894914
NACRES:
NA.32

Nível de qualidade

200

Ensaio

≥95% (HPLC)

nº de adesão UniProt

P02751
P04937
P11276

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N2CCC[C@H]2C(O)=O

InChI

1S/C18H31N7O5/c19-10-14(26)24-8-2-5-12(24)15(27)23-11(4-1-7-22-18(20)21)16(28)25-9-3-6-13(25)17(29)30/h11-13H,1-10,19H2,(H,23,27)(H,29,30)(H4,20,21,22)/t11-,12-,13-/m0/s1

chave InChI

WXPZDDCNKXMOMC-AVGNSLFASA-N

Informações sobre genes

human ... FN1(2335)
mouse ... FN1(14268)
rat ... FN1(25661)

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Amino Acid Sequence

Gly-Pro-Arg-Pro

Descrição geral

Gly-Pro-Arg-Pro is a peptide that mimics the N-terminal Gly-Pro-Arg region in the α chain of fibrin protein.

Aplicação

Gly-Pro-Arg-Pro (GPRP) has been used for the formation of crystal composed of GPRP and the 30kDa C-terminal fragment from the γ chain of fibrinogen (rFbgγC30), cloned and expressed in Pichia pastoris.

Ações bioquímicas/fisiológicas

Gly-Pro-Arg-Pro (GPRP) is capable of increasing free thrombin. Thus it can be utilized to make thrombin-degranulated platelets, which helps in studying platelet reactions.
Gly-Pro-Arg-Pro peptide suppresses the early steps of fibrin polymerization. The amide derivative of this peptide prevents the degradation of fibrinogen and fragment D by plasmin, even in the presence of EGTA (ethylene glycol-bis (β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid).
Inhibits fibrin polymerization.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Fibrinogênio 35-65% protein (≥90% of protein is clottable).

Sigma-Aldrich

F4883

Fibrinogênio

Ramesh Ramapanicker et al.
Bioconjugate chemistry, 24(1), 17-25 (2012-11-16)
The synthetic tetrapeptide GPRP based on the amino-terminal GPR sequence of the fibrin α-chain binds the D-dimer protein with a dissociation constant K(D) of 25 μM. The D-dimer protein, a well-known biomarker for thrombosis, contains two cross-linked D fragments from
Katharina Neubauer et al.
Cytoskeleton (Hoboken, N.J.), 76(1), 131-136 (2018-07-19)
Hereditary neuralgic amyotrophy (HNA) is an autosomal dominant disorder associated with episodic, recurrent, and painful neuropathies affecting the nerves of the brachial plexus. In this study, we report on a family of Lebanese descent with HNA onset in early childhood.
U Haddeland et al.
Thrombosis and haemostasis, 75(2), 326-331 (1996-02-01)
The present paper shows that conformationally changed fibrinogen can expose the sites A alpha-(148-160) and gamma-(312-324) involved in stimulation of the tissue-type plasminogen activator (t-PA)-catalysed plasminogen activation. The exposure of the stimulating sites was determined by ELISA using mABs directed
Silke Niemann et al.
Circulation, 110(2), 193-200 (2004-06-16)
Infective endocarditis (IE) caused by Staphylococcus aureus is associated with significant morbidity and mortality rates. Platelets play a dual role as adhesive cells forming associates with bacteria as well as specialized inflammatory cells. The specific role of the various factors
Andrew L Frelinger et al.
PloS one, 13(9), e0203557-e0203557 (2018-09-27)
Activation of platelet-rich plasma (PRP) by pulse electric field (PEF) releases growth factors which promote wound healing (e.g., PDGF, VEGF for granulation, EGF for epithelialization). To determine after PEF activation of therapeutic PRP: 1) platelet gel strength; 2) profile of
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