F9765

Filipin complex

powder, ≥70% (UV)

• Sinônimo(s): Filimarisin
• Número CAS: 11078-21-0
• Número MDL: MFCD00131073
• Código UNSPSC: 12352202
• NACRES: NA.77

Propriedades

• Nome do produto: Filipin complex from Streptomyces filipinensis, ≥70% (UV)
• fonte biológica: Streptomyces sp. (Streptomyces filipinensis)
• Nível de qualidade: 200
• Ensaio: ≥70% (UV)
• Formulário: powder
• solubilidade: methanol: 9.80-10.20 mg/mL, clear to hazy, yellow to very deep greenish-yellow
• espectro de atividade do antibiótico: fungi
• Modo de ação: cell membrane | interferes
• temperatura de armazenamento: −20°C
• InChI: 1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-,29+,30+,31-,32+,33+,34-/m1/s1
• chave InChI: IMQSIXYSKPIGPD-YQRUMEKGSA-N

Descrição

Descrição geral

Chemical structure: macrolide

Aplicação

Filipin complex from Streptomyces filipinensis has been used as a profluorescence probe to detect the free cholesterol in cell.

Ações bioquímicas/fisiológicas

Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability and associated functions via binding to membrane sterols. Filipin binds to membrane sterols such as cholesterol, and it both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.

Filipin is a polyene macrolide antibiotic and antifungal. The antifungal mechanism of action is unclear but may be due to altering membrane permeability. Filipin binds to model crystalline phase lipid bilayers containing cholesterol, and to liquid phase bilayers with or without cholesterol, in an orientation that forms membrane pores.It both inhibits prion protein (PrP) endocytosis and causes the release of PrP from the plasma membrane.

Outras notas

Filipin contains 8 isomeric components, with filipin III as the major component.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H315,H319,H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable